Вплив інтраопераційного дозованого кріовпливу на функціональну активність щитоподібної залози та імунологічні показники у хворих на вузлову тиреоїдну патологію

• Дата: 2008
• Автори: Karachentsev, Yu. I., Khaziev, V. V., Dubovik, V. M., Lyakh, I. I., Makedonska, V. O., Gerasimenko, L. V.
• Формат: Стаття
• Мова: Ukrainian
• Опубліковано: Publishing House ‘Akademperiodyka’ of the National Academy of Sciences of Ukraine; Institute for Problems of Cryobiology and Cryomedicine 2008
• Теми: вузловий зоб; хірургічне лікування; дозований кріовплив; антитиреоїдні антитіла
• Онлайн доступ: https://cryo.org.ua/journal/index.php/probl-cryobiol-cryomed/article/view/416
• Назва журналу: Problems of Cryobiology and Cryomedicine

In patients with single nodular non-toxic goiter there was studied the content of thyroid hormones, anti-thyroid antibodies, thyroglobulin prior to organ preserving surgical invasion and in 3 and 6 months after operation with using intraoperation dosed cryoeffect. It has been revealed that no clinical and hormonal signs of post-operative hypothyreosis in any patient was found. In both research groups there was revealed statistically significant, progressing rise of average indices of antibodies to thyroperoxidase and during the whole term of research. In the group of patients after standard surgery such a strengthening of autoimmune process proceeded more intensively if compared with the applied cryoeffect (p <0.001). Use of intraoperation dosed cryoeffect inhibits the activation of antithyroid immunity after surgical invasion, that may affect the development of post-operative thyreosis.