Магнітокерований транспорт лікарських препаратів: сучасний стан розробки і перспективи

• Datum: 2010
• Hauptverfasser: Gorbyk, P. P., Dubrovin, I. V., Petranovska, A. L., Turelyk, M. P., Storozhuk, L. P., Mishchenko, V. M., Abramov, M. V., Turanska, S. P., Makhno, S. N., Pilipchuk, E. V., Chekhun, V. F., Lukyanova, N. Ju., Shpak, A. P., Korduban, A. M.
• Format: Artikel
• Sprache: Russisch
• Veröffentlicht: Chuiko Institute of Surface Chemistry National Academy of Sciences of Ukraine 2010
• Online Zugang: https://surfacezbir.com.ua/index.php/surface/article/view/420
• Назва журналу: Surface

The complex of experiments, devoted to scientific grounding of chemical construction of multilevel biocompatible magnetosensitive nanocomposites with hierarchical structure and multifunctional properties (models of biomedical nanorobots) has been carried out. The processes of surface immobilization were studied for bioactive molecules with inherent cytotoxic properties, normal human immunoglobulin (Іg), monoclonal antibodies such as CD 95 with immunotherapeutic and sensory properties. The probability of targeted delivery of pharmaceuticals and the formation of hyperthermia zones were investigated using an external magnetic field influence on the obtained nanorobot models and interaction with cancer cells of epithelial ovarian carcinoma and carcinoma of human breast (lines A 2780 and MCF-7, respectively). The main results of the described research stages allow characterizing the current state of development and the prospects of directed drugs transport problem.