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ПЭО-1500 ингибирует Са2+-АТРазу эритроцитов человека

ПЭО-1500 ингибирует Са2+-АТРазу эритроцитов человека

Human erythrocyte Ca2+-ATPase provides the maintenance and regulation of intercellular calcium level. Change in its functional activity under cryopreservation plays an important role in cell survival and structural integrity preservation. PEO-1500 exocellular cryoprotectant inhibits erythrocyte Ca2+...

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Bibliographic Details
Main Authors: Zemlyanskikh, N. G., Nikolchenko, A. Yu., Babijchuk, L. A.
Format: Article
Language:English
Published: Publishing House ‘Akademperiodyka’ of the National Academy of Sciences of Ukraine; Institute for Problems of Cryobiology and Cryomedicine 2007
Subjects:
еритроцити
Cа2 -АТРаза
кріоконсервування
кріопротектор
поліетиленоксид
Online Access:https://cryo.org.ua/journal/index.php/probl-cryobiol-cryomed/article/view/511
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Summary:Human erythrocyte Ca2+-ATPase provides the maintenance and regulation of intercellular calcium level. Change in its functional activity under cryopreservation plays an important role in cell survival and structural integrity preservation. PEO-1500 exocellular cryoprotectant inhibits erythrocyte Ca2+-ATPase activity at incubation stage but the following freeze-thawing cycle (–196...37°C) in its presence does not affect the settled regimen of this enzyme functioning. The inhibition caused by PEO-1500 effect has a reversible character and the erythrocyte Ca2+-ATPase activity is recovered after its dilution in cell suspension that is essential for cryopreserved cell normal functioning in blood bed after transfusion. The inhibition of Ca2+-ATPase activity is apparently associated to physical and chemical membrane modification under this compound effect.

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