Дизайн, синтез та біологічні властивості комплексів С60 фулерену з лактатами деяких металів

• Datum: 2019
• Hauptverfasser: Мykhailenko, O. V., Petrusenko, S. R., Vitushinska, Ya. O., Prylutskyy, Yu. I., Zavodovskyi, D. O., Мykhailenko, O. O., Lagerna, O. Yu.
• Format: Artikel
• Sprache: Ukrainisch
• Veröffentlicht: Chuiko Institute of Surface Chemistry National Academy of Sciences of Ukraine 2019
• Schlagworte: лактати; C60 фулерен; нанокомплекси C60 фулерену з лактатами металів; м’язова система; ішемія
• Online Zugang: https://www.cpts.com.ua/index.php/cpts/article/view/516
• Назва журналу: Chemistry, Physics and Technology of Surface

The search for new materials based on carbon structures such as fullerenes opens prospects for their use in various application areas, including medicine. That is why the design of supramolecular complexes based on С60 and a natural molecule of the lactic acid (and its derivatives) is a necessary initial step for predicting thermodynamic and kinetic possibilities of synthesizing supramolecular structures and their physical and chemical characterization. The creation of an aqueous form of nanocomplexes and their in vivo testing is the final stage of this research.The design with the ММ+molecular mechanics method, РМ3 semi-empirical quantum-chemical method and Monte-Carlo method allowed us to find the “С60–lactate” to be stable enough at elevated temperatures (up to ~ 550 K). This provides for reliable and stable synthesis of the complexes under regular conditions. There have been synthesized and separated lactates of magnesium, calcium, strontium, zinc and barium. Their chemical structures have been proved by IR-spectroscopy and X-ray structural analysis. Ultrasonic dispergation allowed us to obtain water-soluble complexes of fullerene С60 with the lactates of the above metals. Their structures have been proved by UV-spectroscopy.  The collective in vivo results of mechanical and kinetic investigations of muscle fatigue caused by physical activity indicate that after injecting the С60–lactate, the skeletal muscles are still functioning and the time for their rehabilitation reduces. There has been determined the protective effect of these nanocomplexes on contractile dynamics of ischemic injury of the soleus muscle. The investigation has shown that intramuscular injections of separate components and the С60–lactate nanocomplex demonstrate the significant protective effect due to generation of maximum response strength caused by increased muscle fatigue. Finally, there has been proved the protective role of water-soluble derivatives of C60 in neurodegeneration and the increased hypoxia tolerance of a neural tissue. This offers new opportunities in therapy and preventive treatment of ischemic pathologies.