Возрастные особенности роли оксида азота в механизмах адаптации животных к ритмическим холодовым воздействиям Сообщение 2. Содержание конечных продуктов обмена NO в коре и гипоталамусе головного мозга молодых и старых животных после ритмических холодовых

• Date: 2007
• Main Author: Babijchuk, V. G.
• Format: Article
• Language: English
• Published: Publishing House ‘Akademperiodyka’ of the National Academy of Sciences of Ukraine; Institute for Problems of Cryobiology and Cryomedicine 2007
• Subjects: ритмічні холодові впливи; кінцеві продукти обміну NO; нітрити; блокатори; L-аргінін; гематоенцефалічний бар‘єр
• Online Access: https://cryo.org.ua/journal/index.php/probl-cryobiol-cryomed/article/view/528
• Journal Title: Problems of Cryobiology and Cryomedicine

The experimental results on studying the effect of rhythmical cold effects (RCEs) on the content of NO (nitrites) metabolism final products in brain cortex and hypothalamus of young and aged rats are presented. Nitrite content in brain cortex of young rats was shown to be higher than in aged ones. Applying the blockers of NO-synthase synthesis suppresses their production but L-arginine activator increases it in rats of both age groups. Rhythmical cold effects contribute to the nitrite content augmentation. There was assumed about an important role of blood-brain barrier in animal adaptation to RCEs as well as NO as intracellular mediator, participating in regulation of vegetative functions.