Дослідження впливу допоміжних фармацевтичних речовин на мікров’язкість мембран еритроцитів методом спінових зондів

• Дата: 2015
• Автори: Kartel, M. T., Bezugla, E. P., Ivanov, L. V., Lyapunov, O. M., Nardid, O. A., Kirilyuk, I. A., Cherkashina, Ya. O.
• Формат: Стаття
• Мова: Російська
• Опубліковано: Chuiko Institute of Surface Chemistry National Academy of Sciences of Ukraine 2015
• Онлайн доступ: https://surfacezbir.com.ua/index.php/surface/article/view/594
• Назва журналу: Surface

The new data on the impact of some osmotically active assisting substances (AS) of various structure, molecular weight and different concentrations on microviscosity and permeability of erythrocyte membranes over time were obtained. It has been shown that under the effect of AS in membrane of erythrocytes two differently directed processes occur simultaneously: dehydration of cells with an increased microviscosity of membranes and interaction of the solvent with membrane lipids, accompanying by a decrease in their microviscosity and leading to a disorder of liquid crystal structure and regularity of phospholipids. In many cases this leads to a biphasic changes in viscosity of erythrocyte membranes in time, since both two processes are not synchronized. The effect of  studied AS on microviscosity of erythrocyte membranes, taking into account  the difference in the applied concentrations, can be arranged in the following order: propyleneglycol (PG) <  polyetheleneglycol-300 (PEG-300) < PEG-400 < PEG-1500 < PEG-6000 < PEG-4000 < poloxamer 237 < poloxamer 188 <  hexyleneglycol (HG) <  poloxamer 338 < N-methylpyrrolidone <  poloxamer 407.