Синтез та властивості магніточутливих поліфункціональних нанокомпозитів для застосування в онкології

• Дата: 2017
• Автори: Abramov, M. V., Kusyak, A. P., Kaminskiy, O. M., Turanska, S. P., Petranovska, A. L., Kusyak, N. V., Gorbyk, P. P.
• Формат: Стаття
• Мова: Українська
• Опубліковано: Chuiko Institute of Surface Chemistry National Academy of Sciences of Ukraine 2017
• Теми: магнетит; магніточутливі нанокомпозити; адсорбція; цисплатин; доксорубіцин; магнітні рідини; розмірні параметри наноструктур
• Онлайн доступ: https://surfacezbir.com.ua/index.php/surface/article/view/645
• Назва журналу: Surface

The investigation results are shown directed onto development of the concept of creation of magnetosensitive nanocomposites (NC) with multilevel hierarchical nanoarchitecture and functions of biomedical nanorobots. We synthesized nanosized magnetite in monodomain state and magnetosensitive NC based on that (Fe3O4/dimercaptosuccinic acid (DMSA), Fe3O4/γ-aminopropylsiloxane (γ-APS), Fe3O4/polyacrylamide (PAA), Fe3O4/hydroxyapatite (HA), Fe3O4/SiO2, Fe3O4/TiO2, Fe3O4/Al2О3). Isotherms and adsorption kinetics of cisplatin were studied depending on chemical nature of the surface of nanostructures. Adsorption of doxorubicin (DOX) onto the surface of Fe3O4/HА NC from solution in physiological liquid was studied. Magnetic fluids containing Fe3O4/HА/DOX NC were produced and investigated. Using an ensemble of Fe3O4 carriers as a superparamagnetic probe, Langeven’s paramagnetism theory, we appreciated size parameters of their shell, which was confirmed by independent measurements of specific surface area of the nanostructures and thermodynamic sedimentation stability of the corresponding magnetic fluids. The results obtained may be used in development of new forms of magnetocarried medical remedies for targeted delivery, and adsorbents based on NC of superparamagnetic core-shell type with multilevel nanoarchitecture, and for determination, control and optimization of size parameters of its components.