Enterosorbent silics: properties and clinical application
As a result of the complex physico-chemical and medico-biological studies conducted by the Institute of Surface Chemistry of the NAS of Ukraine together with a number of research institutes and clinics of the Ministry of Public Health of Ukraine a new enterosorbent Silics has been developed and intr...
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| Date: | 2001 |
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| Main Authors: | , , |
| Format: | Article |
| Language: | English |
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Chuiko Institute of Surface Chemistry National Academy of Sciences of Ukraine
2001
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| Online Access: | https://surfacezbir.com.ua/index.php/surface/article/view/68 |
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| author | Chuiko, A. A. Pentyuk, O. O. Pogorelyi, V. K. |
| author_facet | Chuiko, A. A. Pentyuk, O. O. Pogorelyi, V. K. |
| author_institution_txt_mv | [
{
"author": "A. A. Chuiko",
"institution": "Інститут хімії поверхні НАН України"
},
{
"author": "O. O. Pentyuk",
"institution": "Інститут хімії поверхні НАН України"
},
{
"author": "V. K. Pogorelyi",
"institution": "Інститут хімії поверхні НАН України"
}
] |
| author_sort | Chuiko, A. A. |
| baseUrl_str | |
| collection | OJS |
| datestamp_date | 2018-11-27T09:42:39Z |
| description | As a result of the complex physico-chemical and medico-biological studies conducted by the Institute of Surface Chemistry of the NAS of Ukraine together with a number of research institutes and clinics of the Ministry of Public Health of Ukraine a new enterosorbent Silics has been developed and introduced into medicinal practice. This synthetic highly dispersed silica with an extended specific surface is characterized by its chemical purity, stability, and physiological innocuousness. The regular structure of its surface as well as the presence of a large number of surface reactive sites insure a high adsorptive capacity of Silics with respect to water, protein molecules, toxins, pathogenic microorganisms, and viruses. At present new technologies are being described for application of Silics as an individual medicinal preparation of sorptive action and as an active basis for a novel generation of composite drugs. |
| first_indexed | 2025-07-22T19:30:02Z |
| format | Article |
| fulltext |
Е}.{TЕRosoRBЕNT SILIсS
PROPЕRTIЕSANDсLINIСALAPPLICATIOГ{
A.A. Chuiko, O.O. Pеntyulq аnd V.K. Pogorelyi
Itts|itute of Suфсе СhеniStrу, Nаtioпal Асаdеmу' of Sсiеttсеs
Gin. NЬtmoll str, l7, Kуiv-t61,036s0 UKRАINT,
Abstraсt
As a гesult of thе сomplех phуsiсo-сhеmiсal and mеdiсo-biologiсal studiеs
сonduсtеd by thе Instrtute of Surfaсе Сhimistry of thе NAs оf LTkraine togеthег with a
numbег of rеsеarсh insiitutеs and сliniсs of thе Мinistry of Publiс Hеalth of Ukгainе a
nеw еntегosoгbеnt sitiсs has bееn devеlopеd and introduсеd into mеdiсinal pгaсtiсе. Thrs
synthеtiс highlу dispeгsеd siliсa with an еxtеndеd spесifiс suгfaсе is сhaгaсtеrizеd bу its
сhеmiсal purity, *uь,iiц anJ pьysiolоgiсal innoсuouSnеss' Тhe гер1ar structurе of.its
surfaсе as wеll as thе presеn...oi a largе numbеr of suгfaсе rеaсtivе sitеs insurе a high
adsoгptivе сapaсitу of
.sitiсs
with геsресt to watеr, prоtеin molесulеs, toхins, pathogеniс
miсroorganisms, and virusеs' At pгеsеnt nеw tесhnologiеs are bеing dеsсribеd for
"ppil""I""
of siliсs as an individual mеdiсinal pгеparation of sorptivе aсtion and as an
aсiiu" ь"'l' foг a n9vе1 gеnегation of сompositе dгugs'
Introduсtion
ln rесеnt уеars thе еffеrеnt mеthods of trеatmеnt whiсh arе basеd on thе геmoval
of toxiс and ballast substanсеs of ехo- or еndogеnous oгigin from an oгganism havе
dеvеlopеd into an inйp.nс.nt trеnd of modеm pharmaсоthегapу. Меdiсinal soгbеnts
diffеr сonsidегably ln thеir сhеmiсal natuге and pioduсtion pтoсеss and inсludе vaгious
modifiсations of aсtivatеd сhaгсoal, ion-ехсhangе геsins, siliсas, рoiуmегs, and othеr
natuгal and sуnthеtiс substanсes.
SсiеntifiсworkегsofthеInstitutеofSuгiaсеChеmistrуoftheNASofUkraine
and Vinnytsуa Statе Меdiсal Univегsitу namеd aftеr N{,I' Pуrogov havе dеsignеd a nеw
еntеrosorbеnt SILIс. lnd introducеd it into mеdiсinal pгaсtiсе. Тhе еntегosorbеnt is a
sуnthetiс u*o.phous-hi!ьiy аispеrsе siliсa !*si owing tо saliеnt fе.atuге; oг1ts sу.1}1е
HDS is еmploуed noi o"ntуi as a sorbеnt with bioсoгrесting pгopегtiеs but also as a matгlх
usеd in thеЪapaсity of a сaггiег of сompositе mеdiсinal agеnts [1].
FrоmthесhеmiсalstandpointanuсlеusofanгDSрaгtiсlеisathгее-dimеnsional
polymеr whosе ,tl.u"tul.ut units arе siliсon-oхygеn tеtгahеdra bondеd bу disiloxanе
bгidgеs si-o_Si. on the suгfaсе of HDS paпiciеs theге aге gгoups o-H сhеmiсallу
bondеd with siliсon;';; ('il";"l gгoups sioн; Тhе hуdroхyliс сovеr of HDS givеs risе
to a high hуdгophiliсйу Ьi i'' *,iu".^and, сoп.еsponаinщ. to its ability to soгb polar
molеоulеs' espесiatii liui.,
'not..utеs.
ThЪ surfaiе oг rшs has wеak pгoton-donating
p,"p.ni.'.ttsisoеtесt,icpointisaшajnеdatpH=2ThеsuгfaсеоfHDSеntегsintoan
adsorption intегaсtron with сhargеd nlоlесulеs and substanсеs сapab1е of forming
hydrogеnbondso-H..'oThеmесhanismofadsoгptionistoagrеatехtеntdеpеndenton
pH of mеdiu'!z]. .. .гт,^о ..'L:^l. io h'nltоЬf яЬnrlt hv its ohvsiсo-сhеmiсal
Thе matn saliеnt featurе of I{DS whiсh is brought about bу its phуsiсo-сhеmiс
oropеrtiеs is a high |roiеin.soгbing (pгotеinonеktoniс) abilitу that foгms thе basis оf
;;'fi;i;"^;f rDЗ.for rеmoval of &otoхins' endotoхins' pathogеniс immunoсomplехеs,
;iffiffi;;g,й'io" of neсrotiс tissuеs, and othег harmЬ1 substanсеs of pгotеin oгigin
i,orn un o,guni,' as wеll as for fiхation of miсгoorganisms [3].
290
I. Мr
whiсh
l. H;
2нi
3. Fi
4. Ar
еlесtгt
polar
slurгiе
and tr
inflam
diarrhr
siliса
atoms
thrеe
еleсtrс
pгotеir
lntеraс
thе aff
inferеr
mеdiut
оfthe
;
intегaс
2.0) ar
that do
by hyd
albumi
sizе an
modеl
еxudatr
egg alt
havе in
from s
indеpеl
that HI
геsеarс
obsеrvс
thе сasr
(IЕP =
adsorbi
familiar
solutior
pH ofs
toN
'logiсal studiеs
iоgеthеr with a
: oГ LЦсгaine a
i. рraсtiсе. Тhis
.:tегizеd by its
struсturе of its
:s lnsurе a high
:.:.s. pathogеniс
' lеsсгibеd for
::lсin and as an
: r thе rеmoval
.:sanism havе
: :i:al soгbеnts
-:ludе various
:,.:.. and othеr
.. .. S of Ukгainе
...:gnеd a nеw
ш. -
- soгbеnt is a
г:. .iits suгfaсе
i:- aSamatrix
г: .-:imensional
ц disiloхanе
i* - сhеmiсally
r -l S givеs гisе
b soгb polar
,: :r-donating
A :-:3гs into an
b , .I forming
E -::еndеnt on
: '..-сhеmiсal
.э basis of
: эmplехes,
:еin oгigin
I. Mесhanism of Biologiсal Aсfivity of Highly Dispеrse Siliсa (}IDs)
Thе biologiсal aсtivity of SILICS is basеd on the following propегtiеs of HDS
whiсh aгe bгought about by thе сhеmiсal nature of its suгfaсе'
1. High hуdгоphiliсity оf thе suгfaсе of HDS;
2 High biosoгbing aсtivitу
з Fiхatiоn of laгgе amounts of miсrooгganisms and miсrobial toХins;
4, Adsoгption of low-molесulaг substanсеs.
Lеt us сonsidег thеse pгopегtiеs in detail'
l High hуdгophiliсity of HDS is duе to the pгesenсе of a hydroхyliс сovеr and
еlесtгon-aссерting siliсon atoms of silanol groups' Thе suгfaсе of HDS is ablе to soгb
рolar molесulеs' Watег wеts thе suгfaсе of HDS wеll, whiсh lеads tо foгmation оf thin
slurгiеs (suspеnsions) oг gels ofvarious сonsistеnсiеs dеpеnding on thе ingrеdiеnt ratiо'
Тhе hуdrophiiiс propeгtiеs of ЕIDS havе found appliсation to еliminate edemas
and to dесrеasе ехudation in thе сasе of loсal trеatmеnt of wounds at a stagе of
inflammation, tо bind and struсtuгize watег in the intеstinе of a patiеnt suffегing from
diarгhеa. Bеsidеs, НDS is widеlу usеd as a drying agеnt in dеrmatоlogical pгaсtiсе.
2 High pгotеin-sоrbing aсtivity of HDS is еffесted tfuough all rеaсtivе sitеs of
siliсa (hydroхуl grouрs, siliсon atoms of silаnol gгoups' and еlесtгon-donating oхygеn
atoms oГ siloxanе bonds), and, ргobably, thгough сo-ordinativеly bound watеr. Thеrе aге
thrеe tуpеs оf intегaсtion bеtwеen prоtein mоlесulеs and siliсa suгfaсе, namеly
elесtrostatiс intегaсtions, hуdгogen bonding, and hуdrophobiс intегaсtions. Adsorption of
protеin molесulеs on HDS саn bе intегpгеtеd applying a thеoгеtiсal modеl basеd on
intеraсtion of a polуеlесtrol1.tе with a сhaгged surfaсe of HDS. Aссording to this model,
the afIinitу of a pгotеin to thе suгfaсе is dеtегminеd mainly by еlесtrostatiс foгсеs. This
infеrеnсe is сoггoboгatеd by thе dеpеndenсе of adsorption valuе foг thе protеin on pH of
mеdium' with the dеpеndеnсе gгaph displaying a maximum at thе isoеlесtriс point (IЕP)
ofthе protеin [3,4].
Thцs, in the situation with sеrum albumin (IЕP is еqual to about 5.0) thе mutual
intеraсtion is obsегvеd ovеrthе pH intегval fгom thе zeгo-сhaгgе point ofthе suгfaсе (pH
2.0) and to thе protein IЕP when intегaсting agеnts bеar diffeгеnt сhaгgеs. At ptl valuеs
that do not fall within this intеrval thе affrnity will bе dеtеrminеd by othеr faсtoгs, namеly
bу hydrogеn bonds and hydrophobiо intеraсtions. The adsorptiоn valuе maхimum at thе
albumin IЕP is attгibutеd to thе faсt that unсhargеd globules of thе protеin havе minimal
size and a unit suгfaсе may acсommodatе a largег number of thеm.
A study has bееn made of adsorption of pгoteins on HDS within thе sсope of thе
modеl of intегaсtion bеtwееn thе siliсa sorbеnt and biologiс fluids of an oгganism (wound
exudatе, blood sеrum, еtс ). The modеl pгotеins havе bееn bovine sеrum albumin (BSA),
еgg albumin, driеd human blood plаsma, horsе hеmoglobin, gеlatin. Thе kinеtiс tеsts
havе indiсatеd that thе main mass of the pгotеin (not lеss than 90 %) is adsoгbed on HDS
from solution within thе fiгst 10 min of thе сontaсt, with the adsoгption гate being
indеpеndent of typе of pгotеin. A similar high adsoгption ratе maу bе attributed to thе faсt
that HDS has a nonporous struсtuге. As rеgaгds thе influenсе oГ aсidity of mеdium, thе
гesеaгсhеs сonduсtеd havе shown that thе maхimum adsoгption of pгotеins on НDS is
obsеrvеd at pН valuеs с1osе to thе сorrеsponding IЕP of thеsе pгotеins. For instanсе, in
thе сasе of thе bovine sеrum albumin thе maхimum adsoгption valuе is attainеd at pH 5.0
(IЕP = 4 8)
Тhe геsults pгеsеntеd in Tablе l givе еvidеnсе foг thе faсt that thе pгotein-
adsoгbing сapaсity of HDS substantiallу ехcееds thе оoпеsponding сapaсity of othеr
familiar sorbеnts appliеd in the mеdiсinal pгaсtiсе. With inсrеasing ioniс strеngth of
solutions thе adsoгption valuе inсгеasеs' Bеsidеs, thе adsoгptiоn valuе also inсreases as
pH of solutiоns appгoaсh thе IЕP of thе albumin.
pbp
291
нDS BsA 2.7 60 62
Plasma Ъд 90 95
Тablе 1
Dеgrееofrеmoval(in%)ofpгotеinsfтomanaquеousmеdiumbyHDSandothеrmеdiсal
sorbеnts
SUGS BSA 1'8 2,4 3'O
Plasma ы 5.4 46
4.090
60 60 s'3sкN BSA
Plasma
AUVM Dnipгo-МN BSA
Plasmа
\/
10 12
0
14
6.4
l4
n
1.5Debrizan BSA
Plasma
0
0
of inteтеst is also thе following-adsorption potеntialitу 9.f.нDs
In the сasе of
pol'mеr-сontaining dispеrsе. systеms *itь
,1-"..iu-in
iuiio of a Ъolid phasе and adsoгbatе
Ьn. .un obseгvе floсculatioтr ttrat rnvoй ***:{.:'l.,{;T}:.x,Tj:ff- ly;Ё:
;hfi:" :жlH-JТ:HТ'Ы;:,.;iЫ;; iь" ЪoЪ.uiution -pгoсess
гesults in largе
;;;1';:.й:iil'::*:;l.:rун,lliж:rш jжil".iТ':lЦ:':"''l"::
сontaining sуstеms' wl
A study has bееn madе of thе "*;;;;
liJirnу of
-сolloidal
solutions of HDS
as a funсtion of сonсеntгation of u p,o'.in'in;;.;;i;;i"". It has bееn found that thе
prеsenсеofaprotеinаtсonсеntrationslowеrthan4mgml-doеsnotaffесtthestabilitуof
a сolloidal solution ;i"IDil;;a,,sе suсh u^lo* uйount of protеin mo'eсulеs is not
sufТiсiеnt гo. *ut.,".n;i,ii;;aпiсlеs й;;gg;;;;i:s н1 a hish сonсеntration of a
protein (5 mg *l_.;;;'o,.1 tь..ottoiiui-,"T.].iй is stablе J*ing to thе сolloid
protесtion еffеct. Th;^i;;;;.;i,,*.upp., ri.li'-oithе dispегsion stabilitу make up an
inteгval of сonсеntrution, (.quivalеnсе '#i ,"i."ьrе foг flоссulation of a сolloidal
solution of HDS to takе plaсе In tьi, .u*"'u ."Jrroiiы-'oьtion of HDS possеsses a highег
;H:1"'H:*r""i..Tffi"H:xtш*;ь:iщ;i1ЁH'::J.tionbеtwееnHDS
and human ьtood ptasm ^'i,,i;i ew. .uioй.. foi an inсгеasеd affrnitу of dispеrsе siliсa
to iipoprotеiа, in
"o.p",i,on
*itЁp,ot"ln, tьut do not сontain lipids (Tablе 2).
lt сan bе ,""n iьu. dеgrееs oг п*^tionЪf lipids сomponеnts of blood sеrum bу thе
sorbеnt amount to й;;; ;;гe (сholеstеr,ini,;i:;;;)"iwhi'е that of thе total protеin
amount to onlу uьoit ii ,l" Thе inсrеasej,,o|.ion oг 1iчiа.111taining
protеins on thе
siliсa surfaсе is attributеd to fiхation "f 1;;ii]й:p'"l:1lt."i::le
(miсеllе) whose lipid
ohase сontent rs prеdominant.in.o.,p.Т,^.on with thЪ contеflt of othеr phasеs and whose
Ъxtегnal suгfaсе is сovеrеd by protеins H.;i;;;йБ'зi lз' po.'.'' an. inсrеased
affinitу to HDS тn. j"i" ""li".,Ёа
giu..g;;j' to infеr that it.wili bе possible to apply
HDS for eхtгaсorpoia;;;;;й'to,il,' tьЪ сasе of hуpeгlipidеmia [6.l
onthеЬasisofthеabovе-outtinеdobsегvatйsonесan'юЪomеехtеnt,еxplain
hуpolipidеmiс aсtivitly "i
rшs in the .".;;;;;еroгal appliсation bесause lipids in a
sastrointestinur .,u....J,..ь,'i,.Ъ!". "1'i*ri.'
.Ъ"sisting of protеins, phospholipids, and
;lЁ,ffi ,. ii;,
"
;; ; ;; ;;.i o
::-1': 1^iifl r; :Т TtJ ilt.Т.H,Тi1
s thаt ap p еar i n
an intestine as a rеsult ofhеpatoеntеrrс reс
J otheг mеdiсal
lo
1 М Phosphate
Buffег, pH 5.7
62
95
3.0
4.6
In thе сasе of
е and adsorbatе
ц.тiсles through
:еsults in largе
istiс of protеin-
s
l^зtions of HDS
iound that thе
:: thе stability oГ
:oiесulеs is not
:lсеntгation of a
to thе сol1oid
tr makе uр an
of a сolloidal
ssеsses a highеr
,l bеtwееn HDS
lГ dispегse siliсa
е 2).
oc sеrum bу thе
trе total protеin
рrоtеins on thе
:ilе) whosе lipid
lasеs and whosе
ss an inсrеasеd
.оssiblе to applу
) ехtеnt, explain
euse lipids in a
ospholipids, and
ts that appеar in
i thеir
0
5.3
6.4
l4
0
1.5
Tablе 2
Contеnt of pгotеins, lipoрrotеids, anсi сholе-stеrin iп Ьlс;оd 5еr;t;n l.еfоr;. j.i;l ili:.i
tгеatmеnt with FIDS and согrеspondirrg adsогption i'aluеs (рег(:]гlltаgе Of aij:.',, hl.;i
substanсе)
*Тi,nе
oflGй;i _.. ;_. ;.-'.,- .. *...-.'-. --_
---
--fr**ff:Щ_Цs!vlbзЦ-Ч.
Total ргotеin g ]-' .74 o0 58 60 ;Г- -;
% 20.80 21.2 . 25 g
Lоw.dеnsity lipopгoteids g^|-' б.50 0.з8 0 ]З 0 ]О% 9420 9800 98s0
Total lipids g l-' 9'4О 2'2О 1 50 1 j0% 76.6О 84 00 86 2a
Phospholipids gl-' z.Br o2o ot3 oo3% 929О 954 g72О
Triglyсеrrdеs g l-'
1 93 0.38 0 2s 0 18% 8030 8s50 9060
Total сholеstегin mmоl l_1 l l 0O 2 зa 2 50 2 4О% 7800 77Оo 7800
absoгption. It has beеn shown that ingеstion of a mеdiсinai agent dеvеloреd оn thе basisof HDS by patients who suffег for dislurbanсеs of mеtabolisrn-oГlipids aliеaсly *itьlnl*
4 weеks brings about a substantialdесгеasе in thе lеvеl of сholеstеiin in b]oоjsеrum, and
:T:'^*:l"::^'_1'h"
grеatег' thе highег rvas thе initial lеvеl of сhоlеstегin at thе ь.g;;ni;g
oI tnе тгeatment
As is known, soгbents of mеdiсinal spесifiсation must mееt сегtatп геquiremеnts,
with onе of thе most impогtant bеing thеii physiсo.сhеmiсal stability .,p""iutly tь.i,inегtnеss with rеspесt to thе intегnal mеdium Ьf-an oгganism. Suсh a sЬrbеnt sьoutс notbе dissolvеd whеn in сontaсt with biologiс fluids (йudatе of a ц,ound, сontеnt of adigestive tгaсt). From thе геsults aсhiеvеdЪuгing еxpЬгimеnts with tеst animals (rats and
гabbits) it follows that aftег a singlе intragastгiJ administгatiоn of evеn a laгge d;;;f
нDs (1
Ч
ke-,) any statistiсallу ге|iablе vaгrations in сonсеntratiоn of siliсon in blоod aге
not revеalеd. It has bееn found that гats v,,hiсh werе givеn thе abovе-sаid dosе of HDS foг30 days display a tеndеnсy towards inсгеasing in eicrеtion of siliсon. Howеvеr, ;"_tь]'
case any геliability of disagrееmеnts has not bееn vеrifiеd еithеr' onе of thе сausеs of thе
absenсе of any markеd absоrption оf HDS in a digеstivе tгaсt may bе its low solubility
ovег thе pH intегval from 2 to 8. It is also possiblе that thеге is Ь sресifiс physiologiс
m.eсhanism whiсh prеvеnts pеnеtгation of siliсa miсгоpaпiсlеs through intеitinе rvaiis.
Тhus, it has bееn shown that HDS Satisfies оnе of thе most impоrtаnt rеquiгеmеnts to
soгbents of mеdiсinal spесifiсatiоn' namеly it possеssеs a high phj'siсо-сhепliсal stab;liiу
and is not dissolvеd in thе internal mediurn of an oгganism i6]
.. Thе iigh pгоtеin-soгbing ability displayесl ьy гпls шakеs thе basis fоr its
appliсation for fiхation and rеmоval of baсtеrial toхins, pathоgеniс inttl.ttrliО.с.rп'рlе.u*s,
produсts of dесomposition of nесгotiс tissuеs, and other injuгйus substanсеs оf pгоtеin
origin from an oгganism'
3. Thе pгotеin-soгbing pгopегtiеs сhaгaсtеristiс of HDS irnрat1 prеpaгatiоns on itsbasis thе ability to fiх microorganisms. Тhе intегaсtion
.
bеtivсеn siliсa and
miсroorganisms is nоt distinguishеd foг anу speсifiс natuге' It is аttгibutесj rо thе affinitv
ofsiliсapartlсlеstоgl1;сopгоtеidstruсtuгеsandtoрhоsp|lolipidsinmеmbгanеsof
miсrobe сеlls'
A геsеaгсh hаs also bееn madе into intегaсtion of HDS with еntеroрathоgеniс
Еsсhеriсhiа сoti' SnpЬi|;;";;,;; o;,.;,us, Pro|еus,,ulgаris, Bасtllus pуnОсусInеus [7]. Thе
proсеdurе is as folloi,vs. A сегtain amount оf HDS isЪааеа to 3 ml of a diuгnal сulturе of
miсroorgantsms' tnе .i*,ul.. is stiгrеd for 2-3 min and filtrated, following whiсh thе
filtratеisquantitativеlуsоwеdonanutгiеntmеdiumAftеrinсubationfoг24hatЗ7"Сa
сount is takеn of thе сoloniеs grown' Wlttr.;hеiг numbеr bеing еqual to thе numbеr of
bасtегia that wеrе '* п-"J ь," tБе so,Ьеnt Тhе геsults of thе геsеarсhеs shоw that еvеn at
low сonсеntrations of HDS (O 33-l з3 %) pтaсtiсa.llу a1l thе miсrоorganisms whiсh wеrе
in thе solution (up to з's mitliard of miсгobial boiiеs pеr gгammе оf thе sorbеnt) aге
Гrхеd, with thе fixation valuе being viгtualц indеpеndеnt.oftуpе oГ miогоorganisms, Thе
inteгaсtion of the miсгоorganisms with ьшi l', distinguishЪd for somе paгtiсulaгitiеs
Firstly, sizеs of rшi paйсtеs (4 - 40 nm) u,. .oniid.,ab'у smallег thаn thosе of
miсгooгganisms (l _ iо р*), so that HDs sееms to bгing about thе еffесt of
agglutination, whiсh substantiallу inсrеasеs its adsorptivе сaрaсity with rеfегеnсе to
miсrooгganis*, тьu,, ,й" rшs рaгtiсlеs aге muсh sйallеr than miсгobial сеlls, it is thе
soгbеnt paгtiсlеs .1,ui'u.. sorbеd on n",i",.obiul сеlls and not viсе vеrsa. Еvеn at a lo,д,
сonсеntгation,HDSpuni"t.,u,.ablеto'agglutinatеmiсroorganisms'i'е.toaсtinthе
сapaсitу of a g^luе that unitеs miсгoorganisЬ"s into a сonglomетatе. Еvidеntlу' it is this
Dhеnomеnon ot agglutination of *iс,oo,gani,*s bу paпiсlеs of HDS ъ'hiсh ехplains its
unique ability to bind еnormous amоunts of miсrоoгganism.s in сomparison with othеr
sorbеnts. Sесondlу, ii ьu, ь".n found that uft., u .oniu.t of miсrоorganisms with НDS
thеу vaгу so-е of-th"i. p,op..ti"s' Fоr ехamрlе, thеу bесomе morе sеnsitivе to
antibiotiсs, еspесiallу to еry.thгomvсin'-щ1tamУсin. and siгеptom1'сin (from 40.60 % to
10O %) Thiгdly, ut,.,.l .J"i." '"i.ь,lfrs
tь. miсгоorganisms bесomе sеnsitivе to thе
aсtion of proteolу,tiс еЬу-., and оatiоniс and anioniс SAS, suсh as bilе aсids and
phosphоlipids' i е' tо natuгal сomponеnts oi intеstinal and gastriс juiсеs' Thе high affinit1
ofHDStomtсгoorganismsanditsinfluenсеonрroсеssеsofvitalaсtivityоf
miсrooгgani.', p,*й. an ехplanation. foг mесhanism of its сuгativе еffесt bесausе
possibilitу of upp"u.un.Ъ Ьг infе.tiou, disеasеs and gravity.оfthеir progrеss arе dirесtl1
depеndent on valuеs оf сontagious dosе, numbег oГЪaсtегia that aге aссumulatеd in aг
intЪstinе in the сoursе of сolonization,
4 Adsoгption of lorv-molесular substanсеs' of intегеst also arе геsеarсhеs intс
reрlaгitiеs oг uo,o,ption оf mеdiсinul *Б,tun..s on HDS bесausе thе rеsuits of suсi
rеsеarсhеs foгm a sЪiеntiпс basis foг dеvеlopmеnt of pгеparations with a modulatе;
pharmakinеtiсs. A studу has bееn .madе
Ьf adsoгption of oгthophеn, quinidinе
iсooolaminе, amphotеriсin, and somе vitamins on HDS frоm aquеous sоlutions [8].
'""'".";;;;;' o,г.*u'pt., it has bееn
'ьo*n
that in thе сasе of slight'у solublе antibiotl.
atnphoteгiсin B * i';;;ibi"io in.,.u,. thе ratе of absоrption of thе сurativе substanсе b,
simultanеous introс,iсion of the substan.. *d HpS into an intеstinе Whеn amphotеriс:.
B (at a dosе of 3 - i;; ; ;;inistеrеd регorallу' its сonсentration doеs not ехсееd 0.3 m.
ml-l and thе biologiс availabilitу makе's up oniу 1у: Тh:
еxреriment rvas сaггied out с
56 rats subdividеd into 6 gгoups Тhе firstlroф inсludtd anima1s that wеге administеге:
2 ml of o,2 % solution of thе рreparatiй (+. .g) Thе^гats оf gгoups II _ VI ц'е:.
administеrеd z ml oг a miхturе whiсh соntainеd i,mg of amphotегiсin B and diffеге:
amounts оf HDS Thе сontrol gгoup was givеn 2 m1 oidistillеd-watег. Fогthе haif of ::,.
animals thе ехpеrim."i*.' tе"iпlinatеd in"4 h (for the rеSt оf thеm in24 |l) Thе rеsu..
aсhievеd arе рrеsеntеd in Tablе 3
Fгom ,n.
^?u,u, o'.'Ь'.а it .is сlеaг that introduсtion оf thе antibiс:
simultanеouslywithanaquеoЦssuspеnslonofHDSlеadstoaninсrеasеinthеmaхim:.;
сonсеntгation oГthе pгeparation in blood fгom 2 рg ml.1 tо 21 рg rnl_l' Thе shaгр
294
Tablе 3
Variations in сonсеntгation of amphoteгiсin B in blood of rаts
in the сasе of its simultanеous introduсtion tояеthеr with HDS
Gгoup of Animals с"""."t."t." (t.s йт])
4h ./.4 n
llr;ranеs оf
)рathogеniс
,ils [7]' Thе
rl сulturе of
lvhiсh the
latSToCa
rumbеr of
:lat еvеn at
''.. hiсh wеrе
s:гbеnt) aге
з:isms. Thе
:::сulаritiеs.
.: thosе of
'r еffесt of
:еiгеnсe to
-. ls' it is thе
зi at a low
:: aсt in thе
:.. it is this
: ехрlains its
:. .i ith othеr
rs '.r.ith HDS
;: nsitivе to
: :,r-60 %o to
:.. ,ir e tо thе
. зсids and
l - lh affrnitу
.:tivity of
f.:: beсausе
х .:е dirесtly
:. - зlеd in an
s..:сhеs tnto
s..:s of suсh
: nodulated
Е. quinidinе,
ст.. lЗl
щг . antibiotiс
в . .lstanсе bу
r:-.:hotегiсin
.з :.:d 0'3 mg
r:э- зd out on
l i:linistеrеd
t- - VI wеrе
J :.: diffеrеnt
r:: . :.]lf of thе
tl - rе rеsults
I' Amphotеriсin 4 mg + watеr, 2 ml
II. Amphotегiсin 4 mg + HDS, 60 mg kg-l.
IiI' Amphoteriсin 4 mg + HDS, 50 mg kg-'
IV. Amphotегiсin 4 mg + HDs, 30 mg kg-.
V' Amphotеriсin 4 mg + HDS, 20 mg kg_,
.
VI. Amphoteгiсin 4 mg + HDS, 0 2 mg kg-,
2.0t0.1
21.2t0.5
19.1+0.3
14.,7xо,2
9.6t0.3
2 lt0.l
0 910.4
5.4+1.9
6.0+2.5
49+12
41+1 3
0 9t0.3
incгеasе in thе absorption of thе сurativе substanсе providеs an inсгеasе in its biologiс
availabilitу. Aлаlogous еffесts wеrе obsегvеd for substanсеs of other сlassеs, such as
alkaloids (quinidine), сaгbohydгatе (xylоsе)' oгganiс substanсеs (voltarеnе), Thus, thе
studiеs of absoгption showеd that maхimum сonсеntгation of quinidinе in blood inсrеasеd
from 2.6 to 4.6 рg ml-l and that of i'оltaгenе (anti-inflammatory agеnt) fгoпr 16 to 26
.-l
шs ml
Fuгthеr, a studу has bееn сonduсtеd of thе геlеasе of quinidinе (соmmon
antiaггhythmiс prеparation) from various mеdiсinal foгms pгoduсеd by immobilizatior-r of
quinidine and its сomplехеs with suгfaсе aсtive substanсеs or protеin on HDS on thе
basis of the results of thе сompaгаtivе analуsis of thе data of biopharmaсеutiс and
phaгmaсokinеtiс resеaгоhеs it was infeпеd that thе геquiгеmеnts to mеdiсinal agеnts оГ
pгolongеd aсtion aге most fully mеt bу thе pгеpaгation pгoduсеd by сoprесipitatiоn оГ
сomplеxеs of quinidinе with moleсulеs of sеrum albцmin on thе suгfaсе of HDS.
Administгation of this prepaгation does nоt givе гise to anу shaгp pеak of сonсentration of
quinidinе in blood and a slow dесrеase in сonсеntration duгing a long tегm is obsеrvеd.
Bеsidеs, administгation of this mеdiсinal form makеs it possiblе tо pгоvidе thе maхimiпr
bioavalability of quinidine.
Thе rеsults of the сompгеhеnsivе and thorough rеsеarсhеs into phуsiсo.сhеmiсal
and biologiсal propегtiеs of HDS сonduсtеd at thе Vinn1tsуa Statе Мedical Unir,егsity
named aftеr М.I. Pуrogov and at othег mеdiсal institutions of Ukгainе gave gгounds tо
infег that HDS is an aсtivе mеdiсinal su.Dstanсе whiсh on its ou.n сan funсtion as a
thеrapeutiс agеnt, Sогptivе dеtoхiсation with thе aid of HDS brings about a profound
еffесt in thе сasе of aсutе intеstinal infесtions, diaгrhеas of r,aгious gеnеsis, viгal hеpatitis,
as wеll as in thе situation оf lосal tгeatmеnt for pyo.inflammatory disеasеs and purulеnt
wounds. Thе pharmaсotoхiсologiсal tгials of HDS havе substantiatеd innoсuousnеss of its
еntеral and appliсativе usage at dоsеs moгe high than thosе pегmittеd foг its appliсation as
an anсillary sцbstanсе. Thus, thе maхimum dosе of FIDS (l0 g pег kg of a tеst animal
body mass) whiсh was introduсеd into thе stomaсh of an animal provеd to bе nontoхiс.
Singlе and rеpеatеd peroгal administration of HDS at a dose of l00 and 3O0 mg kg-l foг
two spесiеs of animals (rabbits and гats) did not lеad tо anу deviation оf biologiс'
immunologiс, pharmaсologiс or moгphologiс indiсеs Il '4]
II. Cliniсаl Appliсаtion of sILIсs
Тhе data about fiеlds of appliсation of HDS sILIсs at polyсliniсs fог trеatmеnt
for infесtious disеasеs arе prеsеntеd in Table 4
'1г
! -:-
t
lj,
I
:rntibiotiс
:raхimum
...
295
ItissеenthatthеsphеrеofappliсаtiоnofSILIсSisrathегlaгgеandсovегsboth
intеstinal infесtions *j'"'-i""-i'.'-inЪi"ь ui"ti'i," iмunts, as wеll as viral hеpatitisеs,
botulism
Tаblе 4
Сliniсai app1iсatton of SILIСS for trеatmеnt for infесtious diseasеs
цmber of
niсrnоr- Monotheгapу 54
Intеstinal in- Diaгrhе.a, ''ri]:::::il::J .}i-l";::TjloJ''n ;;^-
infесtions intoxiоation, ganlsms ano
(toхi.су,p"p,iu,toi'11,normalizationantibactеrialagеntsand
сoinfeсtions,
9yJlq ."oiuЁ,o.ption
unа agеnts foг rеhуdration
salmonеllosrs есrеtion in GIT
shigеl1osis'
сholегa, еtс.)
Intеstinal Dеhуdration, Sorption of toхins' .Мonothеrapу.
30
toxiсosis in d;;;;;.' Ъlmalization of Combination with А4
сhildrеn in,o*,.uiion,
.abso,ption-and
antibaоtегial agents and
dуspеpsia sесrеtlon,n сtт agеnts foг rеhydration
Viral Cholеstasis, Sorption of virusеs,
-
Мonothеrapу. 3з
hеpatitisеs "r"й;;i
b.ilеасids, and
-
Combinationwith l81
h.p"t;;;;;, biliгubin hepatoproteсtoIs
inioхiсation
Botulism Nеuгotoxiсosis, Soгption of]::::::..:; .""#:'?:':ж1h 103
а,'Ь"p'и hanсеmеnt of aсtion of speсifiс sепlms
I
BywayofillustrationsomесonсгеtеdataarеprеsеntеdinTablе5.Fromthеdata
it is сlеar that inсlusion of SILICS i"l? ::.T*l;:::':lж'#ffli:#fl".'# j,:i
жl..?t:l-T l}:'}1'fi , To,";;#;; БJЬ'l' aсcеl егatеs norm al i z ation of с'i n i с
manifеstations of thеsе Ёi,;;;, ;;;-i..1o, oг *o unа moге. In thе сasе of botulism thе
normalization oя ,y.p,i.",-.i"й*,iui. of lesions of nегvous sуstеm is shoгtеned bу
almost 4 days. tf intеstйl infесtions are not;;;;;;' sшtсs сan.bе reсommеnded as a
;;;';.tь.iuЬ"uti.1..-"."1l"J}i1i.Тff*ffi'';ж::].:'*n.:l :]:""*.
it is moге
еxpеdiеnt to usе lt togg
Inсlusion oг sЁiёs in,o .,.o.pl.- .";;;;;еutiс
ag.еnts
1:,#Jj.:;' .ilТ1i:fl
from viral hеpatitisеs u."ы"'u,"' substantiallу rесovегу ratеs ot pat
noгmal lеvеl of bili.b;;;; ""iir'у "г
alaniiе aminotranspheгasе aIе rесovегеd within
shoгtег r:'i"d:^:l:':".; of the thегapеutiс еffeсt of HDS on treatmеnt foг intеstinal
Thе mеcnantsm
asресts [r]
infесtions sе"ms to involvе thе following ma.;oт
t. Influеnce on intestinаI microJlora:
- u-",,tl:Iъ"jJiT':"xi.J ,n",, rеmoval from an organism *'.'.l'.''ool'' sогption of
miсгobial toxins of ,i..'1^jryi; F j]l;;_|atьJgenlс .protеins
(nеuraminidasе,
hyaluronidasе, сontaсt i.йoiy,i"о that promotе pйogеniс aсtion of miсroorganlsms;
* baсtеriсidal еffесt is possiblе (in thе prеsеn." oiЬit"
"u.iаs
and protеolуtiс еnzуmеs);
B) Indiгеct influеnсе.
296
s both
litisеs,
Number of
Patiеnts
54
..АLLA
JJ
181
103
:е data
a from
i сliniс
:sn thе
::.еd by
е.asa
*i moгe
:Ъгi n o
;': thеiг
:'.'-ithin
::.stinal
*сrеation of сonditions unfavourablе Гoг vital aсtivity of pathogеniс(сonсеntration of miсгooгganisms on thе soгbеnt геsults in a loсal dеfiсrt
aге nесеssary foг thеm, fiхation of hеmoglobin sets a limit on iron thatmiсroorganisms, etс. );*
.adjuvant aсtion (сonсеntration of miсгobial оеIls and thеir toхiпsеnhanсеs thе aлtigеniс aсtiоn and immunе геsрonsе of an o.ganismj.
Tаblе 5
miсгoorganisms
of nutгients that
is nесеssary for
on the sorbеnt
30
144
Duгation of symptoпrs of intеstinal inГесtions in the сouгse of tгeatmеnt with thе aid ofsLICs (М+m)
Duгati on of S ymptoms (du,',; - т.м itййТБut,,'.,t Тгaditional Trеatmеnt + SILIсs
SalmonеlIosis
Diarrhеa 5,60+0'3l
Noгmalization оf сoprоgгаmшеs 5.60*1'0б
Diaггhеa ?ШТJ:;
Noгmalizatron оf сopгogrammеs 7 2o+1 21
Intеstinal toхiсosisеs in сhildгеnIntoxiсatiоn 2.70+О'1з
Dеhуdгation З 70t0 l8
Disturbanсеs of miсгoсiгсu1ation 3 80t0 2l
Bоtuiism (sеvеге сasе)
t3 80+1 39
Dynamiсs of biосhеmiсal indiоеs in thе сouгsе of tгеatmeпt
tis (Мtm
Indiсеs Tгaditional Tгеatmеnt Tгaditional Trеatmеnt + SILIсs
2 00+0.45
2 б010.з5
2 ЗО+g.43
4 00tl 2s
I .80+0. I 2
21О!0.12
21010.35
9 9010.78
of patients suffегing fгom
Nеuгotoхiсosis
Bеforе
Тгеatmеnt
In 7 - 10 Days Befoге
Tгеatmеnt
In7-l0Days
Bilirubin (рmol l-l)
Alaninе aminotrans-
fеrasе (рmol l_l)
264+9 i
3 20:0 65
192t15 9
2 20+О |9
244t28.7
3.00+0.73
t5t!22.8
1.50+0.28
т:Jn of
п:: casе,
2,
. -In||raсtion of HDS with intеstinаl wаlls аnd intеstine contеnt:*.bloсking of гесеptoгs of thе muсous membгanе of thе stomaсь wьlсь arе геsponsible foгadhеsion of miсrooгganisms and fiхation of toхins; intеnsifiсation of tгanspoгt оf wateг,еlесtгolу,tеs, and othеr substanсеs from the intеstinе into intегnal mеdium; modеlling ofbaгoгесеptoгs and сhеmoгесeрtors оf intеstinal wаlIs whiсh u.. ..,pon,iьlе Ьг motilitf;t сlеaranсе of intеstinal juiсе fгоm toхiс substanсеs (produсt, oг uitut aсtivity'ofmiсrоoгganisms and of. miсгobial putгеfaсtion оf protеins), toхlс mеtabolites ofеndogеnous oгigin (bilirubin, bilе aсidi' miсеllе соmplеxеs' mеJium.molесulaг pеptidеs,
еtс.);
* fiхation of сholеstегin. and othег non.polaг lipids bеing membегs of сomplехes withprotеins and phospholipids;
297
*thеsoгbеntpaгtiсlеspeгfoгmthеrolе.ofsitеsofсonсеntгationandtranspoгtof
ingrеdiеnts of thе rntеsiine сontent so that thе soгbеnt aсts as a сoеnzymе theгеby
favouгing thе intеraсtion b.,*."n mеtabolitеs and aсcеlerating the natuгal сoursе of the
Droсеss of thеir t."n,ь.*uiion, whiсh lеads to a dесrеasе in thе amount of intегmеdiatе
рroduсts with toxiс pгopегtiеs;
. , -: r*thееntеrosorbentsрrеsеntinthеgastгointеstinaltractinduсеimmobilizationof
digеstivе еnzymеs -сi"i."liп",
jig.';ion (in paпiсular hуdгolуsш of protеins), whiсh
."du... iпitation "f
i;;;;';'*n.,Ъа aсtivatЬs reaсtions of oхidation' dесomposition
оf peгoxidе сompounds' tгansamination. etс
InthесoursеoГtheabovе-mеntionеdгеaсtionsHDSrеmainsunсhangеdand,
сorrеspondingtу, p,",е*., li, u"tiuity within all thе timе of its rеsidеnсе in thе intеstinе.
Bеsidеs, sILIсj;;ь*"'Ь.ь pгomisе and potentialitу in'сliniсal trеatmеnt foг
intегnal disеasеs. Thе majoг linеs ofrеsеarсhеs into appliсation ofthis pгеpaгation in thе
rеlеvant thеrapy arе prеsentеd in Тable 6
Тablе 6
дi"ii."i* of SILICS for сliniсаl treatmеnt foг infесtious disеasеs
Fiеlds of P"th"l"st. st.т. Рharmaсolоgiс йгtiсularitiеs of Numbеr of
l.lеlds oт гalllurvё|9 JLqr.
Appliсation
- ЕiIесt ApPlt91lt-ql '".ja,."
29
Disturbanсes оf Hуpeгсhоl-
lipoid mеtabolism еstеnnеmla
Rеduсtion of Мonothеrapy
absorption and Combination ц,ithpt Аa
sуnthеsis оf
сholеstегin
statlnеs
Hуpеrtгiglусеri- Rеduсtiоn of Combination with
demia absoгption and niсotiniс aсid and
sуntЬеsis of fibratеs
trig1усeгidеs
Thromboсyaгno. Hypегсюaрlation Retardation of Мonothеraрy.
сoagulativе aggrеgation of Сombination with
homеostasis thromboсуtеs asplгln
Allеrgologу Bгonсhial-asthma, Detoхiсation, Мonothегapу'
food allегgу, soгptlon of immunе Сombinatiоn with
psoгiasis, есzеma сomplехеs antihistaminiс
pгеparatlons'
stеroids
4з
JJ
29
118
138
97
49
250
160
Corrесtion foг Insuffrсiеnt Aссеleгation of Amiodaгonе' 43
еffесt of toxiсitу "гi'"й.y,-'iа.
absoгption' "i.o]ii1..j^ 32
of mеdiсinal еffеcts dесгеasе in dosagе, sуmvastatlnе'
aqеnts
-^^--.-
dеto,
."a'.-. ,
oгth,phеn, qu.n.d.nе 25
ofsignifiсanсеisthеabilitуofsILICstolowеrlеvеlsofсholеsteгinand
triglyсегides as wеll as to rеtaгd aggrеgation oг ,ьio'ьo"1,tеs. Thus, with thе hеlp of
sLIсs it bесomеs po,,iьi".й *.'.й *Ъin patйog.ni" aсtors of athегosсlеrosis, namеlу
hуpегlipidеmia and
'й;;й;i;Б:' ll:l.^:
.ui. oг profound d.isturbanсеs of lipoid
mеtabolism it pгoved advantagеоus to еmploу sшrсs iogеtheг with. othег hypolidеmiс
agеnts. Thе usе "f";h;.;;plеxеs
SILiCi-Ьvasta-tinе (synthеtiс inhibitor оf
bi-osуnthеsis of сholеstе.in-) й"l i' possiblе.to dесгеasе thе dosе of thе lattеr bу a faсtoг
oftwowithoutlowегingofthеintеnsitуofhуpolipodеmicaсtion'Positivеrеsultshavе
298
of
еby
thе
.iate
rof
lrсh
lr.lon
аnd
also been aсhiеvеd with rеfеrеnсе to геduсtion of allеrgiс сompliсations induсеd by
symvastatine and of its hеpatotoxiс aсtion,
SLIсS has also bееn suссessfully еmplоyеd for tгеatmеnt of patiеnts suffегing
from allеrgiс disеases (suсh as bronсhial asthma)' сhгoniс obstгuсtivе lеsions of lungt
food allегgiеs, psoriasis, eczema' Тhе pгofound dеtoxiсation еffесt of $ILIсS and its hйh
afIinity to protеins and mеdium-molесulaг pеptides Гorm thе foundation Гoг its appliсatiБn
for treatmrnt of patiеnts of this profile, Thе rеmotе rеsults of suсh a treatment havе shown
that thе usе of SILICS foг trеatmеnt of patients suffегing from сhгoniс obstruсtive lesions
of lungs makes it possible to produсе a more сompletе and morе prolongеd сuгativе еffесt
in сompaгison with thе tгaditional tгeatmеnt'
Impoгtant fiеlds of aрpliсation of SILIСS aге surgery, stomatologу, onсоlogy,
obstetriсs, and gynесology (Table 7) As far as thеse fiеlds aге сonсегnеd, thеrе arе two
dirrсtions of appliсation of SILICS, namеly as an еntегosoгption agеnt and as an agеnt foг
loсal (aplliсative) usе.
Tаblе 7
Appliсation of SILICS in suгgегv, onсоlog,v, stomatology' obstetгiсs, and gynесology
Fiеlds of Pathologiс Statе Phaгmaсolоgiс ЕfГесt Paпiсulaгitiеs oг шurnbе. ыAppliсation Appliсation Patiеnts
opeгativе Hеmогrhagеs Hеmostasis Appliсations 66
suгgеry
Purulеnt Loсalizеd aегobiс
wounds, and anaегobiс
dеstruсtivе infесtions
pегitonitis, ileus,
purulent
plеurisу,
Onсology Intoхiсation
sуndгomе
:е'
:: :or
j thе
\rmbe. of
Рatiеnts
29
А1
13
]J
29
118
138
91
49
250
160
43
ts
- and
:l of
Stomatolоgy Pyo-
inflammatоry
pгoсеssеs
Gynесology Еndomеtritis,
vaginitis,
pеlviopегitonit is
opeгativе Неmoпhagеs,
obstеtгiсs pyoinflammatory
proсеssеs
Prеgnanсy Gеstosisеs of
pгеgnanсy
Soгption of Aрpliсations, dгainagе 9l
miсгooгganisms, of сavitiеs 56
еndо- and ехotoхins, 36
dеhydгation 25
Sorptiоn ofеndo- and Еntеrosoгption З12
ехotoхins,
сhеmopгеparations
Soгption oi Appliсations, drainagе l56
miсгоoгganisms, of сavities
еndo- and ехotoxins. 286
dеh1,dration' abrasivе
aсtion
Soгption of Appliсations,
miсroorganisms,
еndo. and ехotoхins
lavagе 8з
s6
Мonothегapy. 45
Сombination with
antioхidants 72
Неmostasis, soгption Appliсations, lavagе,
ofmiсroогganisms, сombinationwith
еndo- and ехotoхins, antibaсtегial agеnts 62
loсalizеd dеhvdratiоn:::еlу
E
t:
l:
цц
F
р
р.l|:
:oid
: зпriс
.of
Dеtoхiсatiоn
1avе Loоal appliсativе usе of SILICS maу
wounds, dеstructivе panсгеatitis, pеritonitis,
hаvе muсh promisе in tгеatmеnt foг puгulеnt
puгulеnt plеuгisу, odontogеnous phlеgmons.
299
Thе mесhanism of thе сurative aсtion rеsidеs in sorption of pathogеniс miсroorganlsms
and miсrobial tохtns, i".l.ьyсi"'ion oг-oй tissuеs Тhе loсal appliсativе use ot
sLIсs rеvеals on. n.,o,. ;.lЫ fеatuге
"f
;; ;;;;гutioц ii3:]у
its hеmostatiс еffесt
It has bееn pгovеd th.;Ь;..Ьui., tь. г,,,i pЁu,. of сoagulation of blood, so that it сan
be еmploуеd in thс сasе of modеratе *-'..li.", intеrna.i hеmoгrhagеs. Dеpеnding on
lосalization ot a nеmoгrhagе, .SILIсS i,.;;;d foi appliсations oi foг drainagе and
insufflation' Hеmostasis is uiuallу attainеd aftеr i _ 2 tгеatment proсеduгes involving the
soгbеnt.
WhеnSILiСSisusеdfoг.trеаtmеntofpurulеntwoundsorodontogеnous
оhlеgmons,itехепеf,u-,nu,кес"tт..,on'"uiiй;;";"'-ofadisеasеproсеss,whiсh
Ьuniъ*t, itsеlf in ""ir","й"
oг ь"uting
"г
*Ь""а-, *ith thе. timе intеrval nесessary foг
rеstoration oгtь. n,n.ii;;;i." organ tй.W.'!,iy,.;с bеing shoгtеnеd bу 3 _ 4 days.
ItisalsopossiblеtоеmploуSULICSfortrеatmrnt.inthесasеofpuегpеral
infесtions оссuпing uft., ..,u,.an sесtiоrrr"iu"uЬ" uno drainage of thе сavity of thе
utеrus shortenеd ttrе duiation of fеvег, *ii.i, i".l's tuгn, dесгЪasеd thе timе span of
antibaсtегialthrrapy. s;;ё;;й..up*itу oiappliсations i:..*
ingrеdiеnt for
drainagе is alsо ,';;;'Ь..'чr9vъ1 ьr tгеЬtmепt Гoг gynесoiogiс diseasеs propег
к;Т;'.;йЬiъ::*l;н;l.1i:i{'{Ь"#lЁlmаnifеstsitsе]f
i:vT;":i":j j:ъ:::},
tгeatmеnt of onсotffi,;;;i;; SLlсs seеms to dесгеasе lеvеis of еndogenеous
intoxiсatiоn .nu, *u","u ,lЪ?^"#.", "i
.pшiй"n oi сьеmothегapеutiс prеpaгations
,and
гadiation thеrapу, *:rй lй" .гг,.i.n.у
,;i.;;;;;;';,piion ь.ing сompaгable to that of
plasmaphеrеsis.
Rеfеrеnсеs
1. Chuiko o o', Pеntyuk o o Sсiеntifiс Prinсiplеs of Dеvеlopment of Меdiсinal
Pгеpaгations on,,i..il,,,ЪгЪlgьlу й.*i"" siiса //'Proс of thе Sсiеntifiс Sеsston
of thе о"pu,t-"ш of Сhеmistг, "i
iй"N!i oг uкainе ЬеJi"ut"d to thе 80.h
Annivеrsarу "i;; шдs oг Ukгainе, ;^: i0 Junе, rяsв, Kharkiv, osnova, 1998. -
2' ыfJJ A.A., Gorlov YuI. sу.trт.'9l:ii:'1':|;''i;x,'u,'u." Struсturе, Aсtivе
Sitеs, Soгpti""й;;i;"i'ms. - Kyiv:.Naukova бumka, 1992. .248 pp.
з' Geгashсhenko I.I' Phуsiсo.Chеmiоal ;ъйt.'t;n'Ь.uыop*ent, and Studу of Nеw
Меdiсinal Agеnts on thе вasis oг йj;;i; Ы;p.,sivе Siliсa: Autorеf. Dissегt. foг
Doсtor,s p"g,.Ё'ipйu,",'^...'i.'i кьaiкou, l997 . 39 pp
4. Chuiko o o Ё;; ;ii;;; t; М.di.#;;;Ёi"i"g), -.куi"-stauropol, 1993, 260 pp.
5. Gегashсhеnkо ш. sо.ption of protеi"'
""Ъigьii
Dispеrsе Siliсa, ll L|kу. - |99,7.-
N 3. -P.44-46. lf thе Hуpolipidеmiс Aсtion of Еntеrosorbеnt
6
'^x',ТЁ ;,l,"т''::Нll1lj:yjЬ.!;.;?ъi;iЬ2, - мo*й 1gg2.-.25 pp.'
1. Shtat,ko в.r' i*p.,imеntal Substa"i;;;;;iiБoi,:щ" of Polysorb as an Agent fог
Тгеatmеnt f","x;;;^i;;.,tinul lnг.iй.- дuio,.r Dissегt. for Candidatе's Dеgrее
8. 1Ё;t"iff'^.},ъlijii;.l1",'"':| |ll}Pli::l'''.':,*,f:iЫ,::i;ъТ*
Siliсas
Autоrеf.оissеrt.i",ё*Jш".',p.g.""icьеmist'у;.-Kуiv,1992.-15pp.
|
| id | oai:ojs.pkp.sfu.ca:article-68 |
| institution | Surface |
| keywords_txt_mv | keywords |
| language | English |
| last_indexed | 2025-07-22T19:30:02Z |
| publishDate | 2001 |
| publisher | Chuiko Institute of Surface Chemistry National Academy of Sciences of Ukraine |
| record_format | ojs |
| resource_txt_mv | surfacezbircomua/9d/e33daf3ca977a963edbd7d715739799d.pdf |
| spelling | oai:ojs.pkp.sfu.ca:article-682018-11-27T09:42:39Z Enterosorbent silics: properties and clinical application Enterosorbent silics: properties and clinical application Enterosorbent silics: properties and clinical application Chuiko, A. A. Pentyuk, O. O. Pogorelyi, V. K. As a result of the complex physico-chemical and medico-biological studies conducted by the Institute of Surface Chemistry of the NAS of Ukraine together with a number of research institutes and clinics of the Ministry of Public Health of Ukraine a new enterosorbent Silics has been developed and introduced into medicinal practice. This synthetic highly dispersed silica with an extended specific surface is characterized by its chemical purity, stability, and physiological innocuousness. The regular structure of its surface as well as the presence of a large number of surface reactive sites insure a high adsorptive capacity of Silics with respect to water, protein molecules, toxins, pathogenic microorganisms, and viruses. At present new technologies are being described for application of Silics as an individual medicinal preparation of sorptive action and as an active basis for a novel generation of composite drugs. As a result of the complex physico-chemical and medico-biological studies conducted by the Institute of Surface Chemistry of the NAS of Ukraine together with a number of research institutes and clinics of the Ministry of Public Health of Ukraine a new enterosorbent Silics has been developed and introduced into medicinal practice. This synthetic highly dispersed silica with an extended specific surface is characterized by its chemical purity, stability, and physiological innocuousness. The regular structure of its surface as well as the presence of a large number of surface reactive sites insure a high adsorptive capacity of Silics with respect to water, protein molecules, toxins, pathogenic microorganisms, and viruses. At present new technologies are being described for application of Silics as an individual medicinal preparation of sorptive action and as an active basis for a novel generation of composite drugs. As a result of the complex physico-chemical and medico-biological studies conducted by the Institute of Surface Chemistry of the NAS of Ukraine together with a number of research institutes and clinics of the Ministry of Public Health of Ukraine a new enterosorbent Silics has been developed and introduced into medicinal practice. This synthetic highly dispersed silica with an extended specific surface is characterized by its chemical purity, stability, and physiological innocuousness. The regular structure of its surface as well as the presence of a large number of surface reactive sites insure a high adsorptive capacity of Silics with respect to water, protein molecules, toxins, pathogenic microorganisms, and viruses. At present new technologies are being described for application of Silics as an individual medicinal preparation of sorptive action and as an active basis for a novel generation of composite drugs. Chuiko Institute of Surface Chemistry National Academy of Sciences of Ukraine 2001-06-10 Article Article application/pdf https://surfacezbir.com.ua/index.php/surface/article/view/68 Surface; No. 4-6 (2001): Chemistry, Physics and Technology of Surface; 290-300 Поверхность; № 4-6 (2001): Химия, физика и технология поверхности; 290-300 Поверхня; № 4-6 (2001): Хімія, фізика та технологія поверхні; 290-300 3154-8091 3154-8083 en https://surfacezbir.com.ua/index.php/surface/article/view/68/67 Авторське право (c) 2001 A.A. Chuiko, O.O. Pentyuk, V.K. Pogorelyi |
| spellingShingle | Chuiko, A. A. Pentyuk, O. O. Pogorelyi, V. K. Enterosorbent silics: properties and clinical application |
| title | Enterosorbent silics: properties and clinical application |
| title_alt | Enterosorbent silics: properties and clinical application Enterosorbent silics: properties and clinical application |
| title_full | Enterosorbent silics: properties and clinical application |
| title_fullStr | Enterosorbent silics: properties and clinical application |
| title_full_unstemmed | Enterosorbent silics: properties and clinical application |
| title_short | Enterosorbent silics: properties and clinical application |
| title_sort | enterosorbent silics: properties and clinical application |
| url | https://surfacezbir.com.ua/index.php/surface/article/view/68 |
| work_keys_str_mv | AT chuikoaa enterosorbentsilicspropertiesandclinicalapplication AT pentyukoo enterosorbentsilicspropertiesandclinicalapplication AT pogorelyivk enterosorbentsilicspropertiesandclinicalapplication |