Холодовой стресс как фактор коррекции функциональной архитектоники гематоэнцефалического барьера старых крыс. 1. Фрактальный анализ

• Date: 2012
• Main Authors: Babiychuk, V. G., Marchenko, V. S., Babiychuk, G. A.
• Format: Article
• Language: English
• Published: Publishing House ‘Akademperiodyka’ of the National Academy of Sciences of Ukraine; Institute for Problems of Cryobiology and Cryomedicine 2012
• Subjects: гіпотермія; старіння; гематоенцефалічний бар’єр; ультраструктура; фрактальна морфометрія
• Online Access: https://cryo.org.ua/journal/index.php/probl-cryobiol-cryomed/article/view/71
• Journal Title: Problems of Cryobiology and Cryomedicine

Applying radioisotope methods, those of electron microscopy and fractal morphometry the functional architecture of blood brain barrier (BBB) of 24 month-old rats has been studied. It has been shown that pain and periodic cold effects of low positive and ultralow negative temperatures have structural and functional features of the response of BBB elements which are statistically and significantly found with the indices of fractal dimension (D). At pain and extreme cryoeffects the .D value of brain capillary endothelium monotonously increases up to ~1.5. At periodic effect of hypothermia .D is of manifested rhythmics (anti-persistent periods are found between persistent ones), testifying to a rise in plasticity, but preservation of structure resistance. When cooling the BBB permeability is increased for noradrenalin (if D~1.3) and acetyl choline (at D~1.7).