Визначення стану Т-клітинної ланки імунітету і вмісту стовбурових ракових клітин як критерій оцінки ефективності превентивної терапії раку молочної залози кріоконсервованими клітинами фетальної печінки

The expediency to use cryopreserved fetal liver cells (cFLCs) for preventive treatment of breast cancer (BC) is proved by a wide range of produced by them biologically active substances with immunomodulatory and antineoplastic activity. Revealing cancer stem cells (CSCs) in the mammary gland (MG) an...

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Datum:2014
Hauptverfasser: Goltsev, Anatoliy N., Bondarovich, Nikolay A., Kuznyakov, Andrey V., Ostankov, Maksim V., Ostankova, Lyudmila V., Chelombit'ko, Olga V.
Format: Artikel
Sprache:English
Veröffentlicht: Publishing House ‘Akademperiodyka’ of the National Academy of Sciences of Ukraine; Institute for Problems of Cryobiology and Cryomedicine 2014
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Online Zugang:https://cryo.org.ua/journal/index.php/probl-cryobiol-cryomed/article/view/717
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Назва журналу:Problems of Cryobiology and Cryomedicine

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Problems of Cryobiology and Cryomedicine
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Zusammenfassung:The expediency to use cryopreserved fetal liver cells (cFLCs) for preventive treatment of breast cancer (BC) is proved by a wide range of produced by them biologically active substances with immunomodulatory and antineoplastic activity. Revealing cancer stem cells (CSCs) in the mammary gland (MG) and determination of the immune system (IS) status are the methods of early diagnosis and evaluation of preventive treatment efficiency of breast cancer. The experiments were performed in 16-month-old C3H/He mice which in 6 months were injected by cryopreserved or native FLCs of 14 gestation days at a dose of 1×106 or 5×106 cells. Probl Cryobiol Cryomed 2014; 24(3):238-248.