Исследование апоптотических процессов в клетках моноцитарно-фагоцитарной системы при развитии адъювантного артрита до и после введения криоконсервированных клеток фетальной печени

• Дата: 2014
• Автори: Goltsev, Anatoliy N., Yampolskaya, Ekaterina E., Ostankov, Maksim V., Bondarovich, Nikolay A.
• Формат: Стаття
• Мова: English
• Опубліковано: Publishing House ‘Akademperiodyka’ of the National Academy of Sciences of Ukraine; Institute for Problems of Cryobiology and Cryomedicine 2014
• Теми: апоптоз; моноцитарно-фагоцитарна система; ад'ювантний артрит; клітини фетальної печінки; кріоконсервування
• Онлайн доступ: https://cryo.org.ua/journal/index.php/probl-cryobiol-cryomed/article/view/719
• Назва журналу: Problems of Cryobiology and Cryomedicine

Rheumatoid arthritis (RA) is one of the most widespread chronic inflammatory diseases of the joints with multifactor etiology. A crucial point in RA is the disorder of proliferation and apoptosis in immunocompetent cells as well as in the cells of monocyte-phagocyte system (MPS). Using the model of adjuvant arthritis (AA) in animals we comparatively assessed the development of apoptotic processes in MPS cells before and after administration of native and cryopreserved fetal liver cells (cFLCs). By means of Western blot analysis we showed the peculiarities of CD-95 cascade proteins expression in MPS cells during development of AA. After administration of cFLCs we found more pronounced proapoptotic effect, which degree depended on the period of theiradministration.Probl Cryobiol Cryomed 2014; 24(3):249-261.