Медичні нанокомпозити на базі гідрофільних та гідрофобних кремнеземів та їхні властивості

• Date: 2025
• Main Authors: Крупська, Т. В., Борисенко, М. В., Клименко, Н. Ю., Зроль, Л. В., Новікова, О. А., Туров, В. В.
• Format: Article
• Language: English
• Published: Chuiko Institute of Surface Chemistry National Academy of Sciences of Ukraine 2025
• Subjects: гідрофільний та гідрофобний кремнеземи; пектин; інулін; бетулін; бурштинова кислота; композитні системи; сильно- та слабоасоційована вода
• Online Access: https://surfacezbir.com.ua/index.php/surface/article/view/814
• Journal Title: Surface

Technologies have been developed for the production of nanocomposite systems based on hydrophilic and hydrophobic silicas or their mixtures with biologically active plant-based compounds, such as betulin, pectin and inulin. The physicochemical properties and structure of the adsorption layer have been studied, and the concentration ratios of the components at which the active substances are in their most active, nanoscale state have been determined. Information has been obtained on the possibilities of regulating the release rate of biologically active components from composite systems. Inulin and other bioactive substances (BAS) forms composite systems with hydrophilic or a mixture of hydrophilic and hydrophobic silica during mechanical processing, maintaining a high specific surface area of the composite system. At the same time BAS are uniformly distributed on the surface of mineral particles. Both in initial materials and in composite systems, adsorbed water is in the form of nanoscale or subnanoscale clusters formed by strongly-associated water, molecules of which simultaneously participate in the formation of 2–3 hydrogen bonds. A weakly polar organic medium has a disordering (chaotropic) effect on water. As the temperature decreases, the ordering of adsorbed water molecules increases, although in some systems, temperature intervals are fixed at which the cosmotropic effect of the surface on adsorbed water takes place. The addition of hydrophobic silica AM-1 to the A-300/BAS composite system leads to an increase in the surface-water interaction. The magnitude of the interfacial energy correlates with a decrease in the radius of the adsorbed water clusters. Aqueous gels created from silica and BAS exhibit the properties of non-Newtonian fluids, which depending on the magnitude of shear strain can exhibit both pseudoplastic and dilatant properties.