СИНТЕТИЧНІ ФУЛЬВОКИСЛОТИ З ОПЛОДНЯ ГРАНАТУ
It is known that fulvic acids (FA) have a whole complex of therapeutic properties, but their widespread introduction into medical practice is limited by the dependence of the properties of the final product on the source of their extraction. In this regard, research aimed at developing experimental...
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| Datum: | 2020 |
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| Format: | Artikel |
| Sprache: | English |
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V.I.Vernadsky Institute of General and Inorganic Chemistry
2020
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oai:ojs2.1444248.nisspano.web.hosting-test.net:article-1362020-05-27T11:34:11Z SYNTHETIC FULVIC ACIDS FROM POMEGRANATE PEEL СИНТЕТИЧЕСКИЕ ФУЛЬВОКИСЛОТЫ С ОКОЛОПЛОДНИКА ГРАНАТА СИНТЕТИЧНІ ФУЛЬВОКИСЛОТИ З ОПЛОДНЯ ГРАНАТУ Litvin, Valentina humic substances, synthetic fulvic acids, elagotanins, lignin It is known that fulvic acids (FA) have a whole complex of therapeutic properties, but their widespread introduction into medical practice is limited by the dependence of the properties of the final product on the source of their extraction. In this regard, research aimed at developing experimental approaches for the production of synthetic substances that are similar in structure, physical, chemical and therapeutic properties to natural FA, but characterized by standardized and controlled parameters, is of interest. The purpose of the work was to develop a method of obtaining synthetic FA using as a precursor ellagitannins and lignin extracted from pomegranate peels and comprehensive study of their properties. As a result of the experiment and the analysis of the results it was found that the elagotanins and lignin contained in the peel of pomegranate can be used as a precursor to obtain synthetic FA. Comparative analysis of the elemental composition and spectral characteristics of synthetic FA with the literature data for natural FA allowed to ascertain the uniformity of their chemical structure. X-ray diffraction analysis of synthetic FA indicates their amorphous nature, which is typical of natural FA as well. The content of basic acid groups in the structure of synthetic FAs and their recovery capacity are calculated. In particular, the content of carboxyl groups is 2.7 ± 0.2 mmol/g, and the phenolic groups - 6.0 ± 0.1 mmol/g; the recovery capacity is 5.2 ± 0.3 mmol/g. The SEM images of the dried synthetic FA preparations show the uniformity of the powder particles obtained. However, unlike natural FA, synthetic analogues obtained by the developed method are characterized by controlled and reproducible properties, which greatly expands their use in medicine. V.I.Vernadsky Institute of General and Inorganic Chemistry 2020-04-07 Article Article Organic chemistry Органическая xимия Органічна xімія application/pdf https://ucj.org.ua/index.php/journal/article/view/136 10.33609/0041-6045.86.3.2020.48-60 Ukrainian Chemistry Journal; Vol. 86 No. 3 (2020): Ukrainian Chemistry Journal; 48-60 Украинский химический журнал; Том 86 № 3 (2020): Украинский химический журнал; 48-60 Український хімічний журнал; Том 86 № 3 (2020): Український хімічний журнал; 48-60 2708-129X 2708-1281 en https://ucj.org.ua/index.php/journal/article/view/136/89 |
| institution |
Ukrainian Chemistry Journal |
| baseUrl_str |
|
| datestamp_date |
2020-05-27T11:34:11Z |
| collection |
OJS |
| language |
English |
| topic_facet |
humic substances synthetic fulvic acids elagotanins lignin |
| format |
Article |
| author |
Litvin, Valentina |
| spellingShingle |
Litvin, Valentina СИНТЕТИЧНІ ФУЛЬВОКИСЛОТИ З ОПЛОДНЯ ГРАНАТУ |
| author_facet |
Litvin, Valentina |
| author_sort |
Litvin, Valentina |
| title |
СИНТЕТИЧНІ ФУЛЬВОКИСЛОТИ З ОПЛОДНЯ ГРАНАТУ |
| title_short |
СИНТЕТИЧНІ ФУЛЬВОКИСЛОТИ З ОПЛОДНЯ ГРАНАТУ |
| title_full |
СИНТЕТИЧНІ ФУЛЬВОКИСЛОТИ З ОПЛОДНЯ ГРАНАТУ |
| title_fullStr |
СИНТЕТИЧНІ ФУЛЬВОКИСЛОТИ З ОПЛОДНЯ ГРАНАТУ |
| title_full_unstemmed |
СИНТЕТИЧНІ ФУЛЬВОКИСЛОТИ З ОПЛОДНЯ ГРАНАТУ |
| title_sort |
синтетичні фульвокислоти з оплодня гранату |
| title_alt |
SYNTHETIC FULVIC ACIDS FROM POMEGRANATE PEEL СИНТЕТИЧЕСКИЕ ФУЛЬВОКИСЛОТЫ С ОКОЛОПЛОДНИКА ГРАНАТА |
| description |
It is known that fulvic acids (FA) have a whole complex of therapeutic properties, but their widespread introduction into medical practice is limited by the dependence of the properties of the final product on the source of their extraction. In this regard, research aimed at developing experimental approaches for the production of synthetic substances that are similar in structure, physical, chemical and therapeutic properties to natural FA, but characterized by standardized and controlled parameters, is of interest. The purpose of the work was to develop a method of obtaining synthetic FA using as a precursor ellagitannins and lignin extracted from pomegranate peels and comprehensive study of their properties. As a result of the experiment and the analysis of the results it was found that the elagotanins and lignin contained in the peel of pomegranate can be used as a precursor to obtain synthetic FA. Comparative analysis of the elemental composition and spectral characteristics of synthetic FA with the literature data for natural FA allowed to ascertain the uniformity of their chemical structure. X-ray diffraction analysis of synthetic FA indicates their amorphous nature, which is typical of natural FA as well. The content of basic acid groups in the structure of synthetic FAs and their recovery capacity are calculated. In particular, the content of carboxyl groups is 2.7 ± 0.2 mmol/g, and the phenolic groups - 6.0 ± 0.1 mmol/g; the recovery capacity is 5.2 ± 0.3 mmol/g. The SEM images of the dried synthetic FA preparations show the uniformity of the powder particles obtained. However, unlike natural FA, synthetic analogues obtained by the developed method are characterized by controlled and reproducible properties, which greatly expands their use in medicine. |
| publisher |
V.I.Vernadsky Institute of General and Inorganic Chemistry |
| publishDate |
2020 |
| url |
https://ucj.org.ua/index.php/journal/article/view/136 |
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2025-09-24T17:43:24Z |
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2025-09-24T17:43:24Z |
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