SYNTHESIS AND BIOLOGICAL ACTIVITY OF 3d-METAL COMPLEXES WITH BIS(PHOSPHONOMETHYL)AMINOSUNRIC ACID
New complexes of 3d-metals (Co2+, Ni2+, Zn2+) with bis(phosphonomethyl)aminosuccinic acid (H6BPMAS) have been synthesized. The complexes were studied in aqueous solutions at ratios M2+:H6BPMAS = 1:1 in a wide pH range (1÷10). Regardless of the nature of the metal, the formation of complexes of the g...
Saved in:
| Date: | 2022 |
|---|---|
| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
| Published: |
V.I.Vernadsky Institute of General and Inorganic Chemistry
2022
|
| Online Access: | https://ucj.org.ua/index.php/journal/article/view/478 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Journal Title: | Ukrainian Chemistry Journal |
Institution
Ukrainian Chemistry Journal| id |
oai:ojs2.1444248.nisspano.web.hosting-test.net:article-478 |
|---|---|
| record_format |
ojs |
| spelling |
oai:ojs2.1444248.nisspano.web.hosting-test.net:article-4782022-11-20T23:17:14Z SYNTHESIS AND BIOLOGICAL ACTIVITY OF 3d-METAL COMPLEXES WITH BIS(PHOSPHONOMETHYL)AMINOSUNRIC ACID Trunova , Elena Rusakova, Mariya Makotryk, Tamara Artamonova, Ganna complexes, aminocarboxyphosphonates, cobalt, nickel, zinc, synthesis, biological activity. New complexes of 3d-metals (Co2+, Ni2+, Zn2+) with bis(phosphonomethyl)aminosuccinic acid (H6BPMAS) have been synthesized. The complexes were studied in aqueous solutions at ratios M2+:H6BPMAS = 1:1 in a wide pH range (1÷10). Regardless of the nature of the metal, the formation of complexes of the general composition [M(HnBPMAS)(OH)m] (n= 4÷0, m=1÷0) is shown. The stability constants of the formed differently protonated complexes are calculated and diagrams of their distribution are plotted. It is shown that the process of complexation takes place most completely in the region of pH>4. For all bis(phosphonomethyl)aminosuccinates of 3d metals, the dominance of the complex with one form of the ligand occurs in approximately the same pH ranges. A close order of change in the values of lgKst. complexes testifies to the same type of structure of their internal coordination sphere. Solid complexes of the composition Na4[MBPMAS]⋅4H2O were synthesized. Their composition, structure, and thermal characteristics were determined by the set of methods such as diffuse reflectance spectroscopy, IR spectroscopy, DTA and non-quantitative mass spectrometry. It is proved that the complexes have the structure of a distorted octahedron, in which the 3-d metal ions are bound to the oxygen atoms of the carboxyl and phosphonic groups and the tertiary nitrogen atom of the ligand. At the same time, two 5-membered (aminomethylenephosphonic and glycine) and one 6-membered (β-alanine) metallocycles are formed in bis(phosphonomethyl)aminosuccinates. The biological activity of H6BPMAS and its complexes with Ni(II) and Co(II) against non-pathogenic bacterial species of microorganisms Pseudomonas fluorescens and Pseudomonas aureofaciens was studied. The study of the activity of substances was carried out in a liquid sterile Hiss medium. The maximum stimulating effect on the growth of bacterial cultures for the studied compounds was recorded at a concentration of 1 µM in 24 hours after the start of cultivation of microorganisms. The highest growth of microorganisms was recorded for metal complexes (50% Na4[CoBPMAS]·4H2O and 35% Na4[NiBPMAS]·4H2O). The maximum stimulating effect on the growth of bacterial cultures is shown by the Co(II) complex, which is able to initiate the synthesis of one of the most important growth hormones - heteroauxin. V.I.Vernadsky Institute of General and Inorganic Chemistry 2022-10-28 Article Article Inorganic Chemistry Неорганическая химия Неорганічна хімія application/pdf https://ucj.org.ua/index.php/journal/article/view/478 10.33609/2708-129X.88.09.2022.3-24 Ukrainian Chemistry Journal; Vol. 88 No. 9 (2022): Ukrainian Chemistry Journal; 3-24 Украинский химический журнал; Том 88 № 9 (2022): Ukrainian Chemistry Journal; 3-24 Український хімічний журнал; Том 88 № 9 (2022): Український хімічний журнал; 3-24 2708-129X 2708-1281 en https://ucj.org.ua/index.php/journal/article/view/478/245 |
| institution |
Ukrainian Chemistry Journal |
| baseUrl_str |
|
| datestamp_date |
2022-11-20T23:17:14Z |
| collection |
OJS |
| language |
English |
| topic_facet |
complexes aminocarboxyphosphonates cobalt nickel zinc synthesis biological activity. |
| format |
Article |
| author |
Trunova , Elena Rusakova, Mariya Makotryk, Tamara Artamonova, Ganna |
| spellingShingle |
Trunova , Elena Rusakova, Mariya Makotryk, Tamara Artamonova, Ganna SYNTHESIS AND BIOLOGICAL ACTIVITY OF 3d-METAL COMPLEXES WITH BIS(PHOSPHONOMETHYL)AMINOSUNRIC ACID |
| author_facet |
Trunova , Elena Rusakova, Mariya Makotryk, Tamara Artamonova, Ganna |
| author_sort |
Trunova , Elena |
| title |
SYNTHESIS AND BIOLOGICAL ACTIVITY OF 3d-METAL COMPLEXES WITH BIS(PHOSPHONOMETHYL)AMINOSUNRIC ACID |
| title_short |
SYNTHESIS AND BIOLOGICAL ACTIVITY OF 3d-METAL COMPLEXES WITH BIS(PHOSPHONOMETHYL)AMINOSUNRIC ACID |
| title_full |
SYNTHESIS AND BIOLOGICAL ACTIVITY OF 3d-METAL COMPLEXES WITH BIS(PHOSPHONOMETHYL)AMINOSUNRIC ACID |
| title_fullStr |
SYNTHESIS AND BIOLOGICAL ACTIVITY OF 3d-METAL COMPLEXES WITH BIS(PHOSPHONOMETHYL)AMINOSUNRIC ACID |
| title_full_unstemmed |
SYNTHESIS AND BIOLOGICAL ACTIVITY OF 3d-METAL COMPLEXES WITH BIS(PHOSPHONOMETHYL)AMINOSUNRIC ACID |
| title_sort |
synthesis and biological activity of 3d-metal complexes with bis(phosphonomethyl)aminosunric acid |
| description |
New complexes of 3d-metals (Co2+, Ni2+, Zn2+) with bis(phosphonomethyl)aminosuccinic acid (H6BPMAS) have been synthesized. The complexes were studied in aqueous solutions at ratios M2+:H6BPMAS = 1:1 in a wide pH range (1÷10). Regardless of the nature of the metal, the formation of complexes of the general composition [M(HnBPMAS)(OH)m] (n= 4÷0, m=1÷0) is shown. The stability constants of the formed differently protonated complexes are calculated and diagrams of their distribution are plotted. It is shown that the process of complexation takes place most completely in the region of pH>4. For all bis(phosphonomethyl)aminosuccinates of 3d metals, the dominance of the complex with one form of the ligand occurs in approximately the same pH ranges. A close order of change in the values of lgKst. complexes testifies to the same type of structure of their internal coordination sphere.
Solid complexes of the composition Na4[MBPMAS]⋅4H2O were synthesized. Their composition, structure, and thermal characteristics were determined by the set of methods such as diffuse reflectance spectroscopy, IR spectroscopy, DTA and non-quantitative mass spectrometry. It is proved that the complexes have the structure of a distorted octahedron, in which the 3-d metal ions are bound to the oxygen atoms of the carboxyl and phosphonic groups and the tertiary nitrogen atom of the ligand. At the same time, two 5-membered (aminomethylenephosphonic and glycine) and one 6-membered (β-alanine) metallocycles are formed in bis(phosphonomethyl)aminosuccinates.
The biological activity of H6BPMAS and its complexes with Ni(II) and Co(II) against non-pathogenic bacterial species of microorganisms Pseudomonas fluorescens and Pseudomonas aureofaciens was studied. The study of the activity of substances was carried out in a liquid sterile Hiss medium. The maximum stimulating effect on the growth of bacterial cultures for the studied compounds was recorded at a concentration of 1 µM in 24 hours after the start of cultivation of microorganisms. The highest growth of microorganisms was recorded for metal complexes (50% Na4[CoBPMAS]·4H2O and 35% Na4[NiBPMAS]·4H2O). The maximum stimulating effect on the growth of bacterial cultures is shown by the Co(II) complex, which is able to initiate the synthesis of one of the most important growth hormones - heteroauxin. |
| publisher |
V.I.Vernadsky Institute of General and Inorganic Chemistry |
| publishDate |
2022 |
| url |
https://ucj.org.ua/index.php/journal/article/view/478 |
| work_keys_str_mv |
AT trunovaelena synthesisandbiologicalactivityof3dmetalcomplexeswithbisphosphonomethylaminosunricacid AT rusakovamariya synthesisandbiologicalactivityof3dmetalcomplexeswithbisphosphonomethylaminosunricacid AT makotryktamara synthesisandbiologicalactivityof3dmetalcomplexeswithbisphosphonomethylaminosunricacid AT artamonovaganna synthesisandbiologicalactivityof3dmetalcomplexeswithbisphosphonomethylaminosunricacid |
| first_indexed |
2025-09-24T17:43:46Z |
| last_indexed |
2025-09-24T17:43:46Z |
| _version_ |
1849658123492524032 |