СOMPLEXES OF Nd(III) AND 3d-METALS BASED ON ETHYLENEDIAMINEDISUCCINIC ACID AS POTENTIAL ANTIFUNGAL AGENTS
Neodymium heterometallic complexes [(NdМIIEDDS)(H2O)6]∙n2H2O (МII=Zn, Co; n = 3; 2) were synthesized by the «block» synthesis method using protonated ethylenediaminedisuccinate of the 3-d metal and NdIII nitrate. The complexes were characterized by spectroscopic methods (UV-VIS electronic absorption...
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| Дата: | 2023 |
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| Автори: | , , , , |
| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
V.I.Vernadsky Institute of General and Inorganic Chemistry
2023
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| Онлайн доступ: | https://ucj.org.ua/index.php/journal/article/view/592 |
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| Назва журналу: | Ukrainian Chemistry Journal |
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oai:ojs2.1444248.nisspano.web.hosting-test.net:article-5922024-10-06T14:15:22Z СOMPLEXES OF Nd(III) AND 3d-METALS BASED ON ETHYLENEDIAMINEDISUCCINIC ACID AS POTENTIAL ANTIFUNGAL AGENTS Trunova, Olena Berezhnytska , Оleksandra Rohovtsov , Oleksandr Makotryk, Tamara Rusakova, Mariya ethylenediaminedisuccinates complexes, neodymium, cobalt (II), zinc (ІІ), antifungal properties. Neodymium heterometallic complexes [(NdМIIEDDS)(H2O)6]∙n2H2O (МII=Zn, Co; n = 3; 2) were synthesized by the «block» synthesis method using protonated ethylenediaminedisuccinate of the 3-d metal and NdIII nitrate. The complexes were characterized by spectroscopic methods (UV-VIS electronic absorption spectroscopy and FT-IR) and elemental analysis. It is shown that the f-d-complexes belong to the «folded» type complexes, in which the ligand-EDDS realizes the maximum dentateness to NdIII, and the coordination sphere of the 3-d cation is formed by chain carboxyl groups of EDDS and intraspherical water molecules. At the same time, the cations of 3d metals are in a distorted octahedral environment, and the coordination polyhedron of the neodymium ion corresponds to a square antiprism (C4v) with the coordination number NdIII = 8. In solutions and in the solid state, the complexes have the same type of structure. The sensitivity of various morphological forms of Candida albicans in Spider and Saburo media to neodymium complexes NdIII with ethylene diamine disuccinate: NdEDDS (I), NdEDDSZn (II) NdEDDSСo (III) in the range of concentrations of the studied compounds 1; 10 and 100 μM was studied. It is shown that the antifungal properties of the complexes vary in the range NdEDDSСo> NdEDDSZn ≥ NdEDDS. The inhibition index of C. albicans in the composition of the biofilm in the Saburo medium under the action of the complexes was 20–25% of the control value, and in the Spider medium the complexes led to 95% of cell death. V.I.Vernadsky Institute of General and Inorganic Chemistry 2023-11-24 Article Article Inorganic Chemistry Неорганическая химия Неорганічна хімія application/pdf https://ucj.org.ua/index.php/journal/article/view/592 10.33609/2708-129X.89.10.2023.85-99 Ukrainian Chemistry Journal; Vol. 89 No. 10 (2023): Ukrainian Chemistry Journal; 85-99 Украинский химический журнал; Том 89 № 10 (2023): Ukrainian Chemistry Journal; 85-99 Український хімічний журнал; Том 89 № 10 (2023): Український хімічний журнал; 85-99 2708-129X 2708-1281 en https://ucj.org.ua/index.php/journal/article/view/592/303 |
| institution |
Ukrainian Chemistry Journal |
| baseUrl_str |
|
| datestamp_date |
2024-10-06T14:15:22Z |
| collection |
OJS |
| language |
English |
| topic_facet |
ethylenediaminedisuccinates complexes neodymium cobalt (II) zinc (ІІ) antifungal properties. |
| format |
Article |
| author |
Trunova, Olena Berezhnytska , Оleksandra Rohovtsov , Oleksandr Makotryk, Tamara Rusakova, Mariya |
| spellingShingle |
Trunova, Olena Berezhnytska , Оleksandra Rohovtsov , Oleksandr Makotryk, Tamara Rusakova, Mariya СOMPLEXES OF Nd(III) AND 3d-METALS BASED ON ETHYLENEDIAMINEDISUCCINIC ACID AS POTENTIAL ANTIFUNGAL AGENTS |
| author_facet |
Trunova, Olena Berezhnytska , Оleksandra Rohovtsov , Oleksandr Makotryk, Tamara Rusakova, Mariya |
| author_sort |
Trunova, Olena |
| title |
СOMPLEXES OF Nd(III) AND 3d-METALS BASED ON ETHYLENEDIAMINEDISUCCINIC ACID AS POTENTIAL ANTIFUNGAL AGENTS |
| title_short |
СOMPLEXES OF Nd(III) AND 3d-METALS BASED ON ETHYLENEDIAMINEDISUCCINIC ACID AS POTENTIAL ANTIFUNGAL AGENTS |
| title_full |
СOMPLEXES OF Nd(III) AND 3d-METALS BASED ON ETHYLENEDIAMINEDISUCCINIC ACID AS POTENTIAL ANTIFUNGAL AGENTS |
| title_fullStr |
СOMPLEXES OF Nd(III) AND 3d-METALS BASED ON ETHYLENEDIAMINEDISUCCINIC ACID AS POTENTIAL ANTIFUNGAL AGENTS |
| title_full_unstemmed |
СOMPLEXES OF Nd(III) AND 3d-METALS BASED ON ETHYLENEDIAMINEDISUCCINIC ACID AS POTENTIAL ANTIFUNGAL AGENTS |
| title_sort |
сomplexes of nd(iii) and 3d-metals based on ethylenediaminedisuccinic acid as potential antifungal agents |
| description |
Neodymium heterometallic complexes [(NdМIIEDDS)(H2O)6]∙n2H2O (МII=Zn, Co; n = 3; 2) were synthesized by the «block» synthesis method using protonated ethylenediaminedisuccinate of the 3-d metal and NdIII nitrate. The complexes were characterized by spectroscopic methods (UV-VIS electronic absorption spectroscopy and FT-IR) and elemental analysis. It is shown that the f-d-complexes belong to the «folded» type complexes, in which the ligand-EDDS realizes the maximum dentateness to NdIII, and the coordination sphere of the 3-d cation is formed by chain carboxyl groups of EDDS and intraspherical water molecules. At the same time, the cations of 3d metals are in a distorted octahedral environment, and the coordination polyhedron of the neodymium ion corresponds to a square antiprism (C4v) with the coordination number NdIII = 8. In solutions and in the solid state, the complexes have the same type of structure. The sensitivity of various morphological forms of Candida albicans in Spider and Saburo media to neodymium complexes NdIII with ethylene diamine disuccinate: NdEDDS (I), NdEDDSZn (II) NdEDDSСo (III) in the range of concentrations of the studied compounds 1; 10 and 100 μM was studied. It is shown that the antifungal properties of the complexes vary in the range NdEDDSСo> NdEDDSZn ≥ NdEDDS. The inhibition index of C. albicans in the composition of the biofilm in the Saburo medium under the action of the complexes was 20–25% of the control value, and in the Spider medium the complexes led to 95% of cell death. |
| publisher |
V.I.Vernadsky Institute of General and Inorganic Chemistry |
| publishDate |
2023 |
| url |
https://ucj.org.ua/index.php/journal/article/view/592 |
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2025-09-24T17:43:53Z |
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