POLYLECTROLYTE COMPLEX OF SODIUM ALGINATE - POLYETHYLENIMINE WITH THE INCLUSION COMPLEX OF SULFOBUTYL ETHER β-CYCLODEXTRIN – DEXAMETHASONE.
A polyelectrolyte complex (PEC) of sodium alginate with polyethyleneimine, loaded with (5 wt.%) inclusion complex (IC) of sulfobutylether β-cyclodextrin with dexamethasone, was formed from aqueous solutions. Dexamethasone (DM) is a medical and veterinary synthetic glucocorticosteroid with anti-inf...
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| Date: | 2023 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
| Published: |
V.I.Vernadsky Institute of General and Inorganic Chemistry
2023
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| Online Access: | https://ucj.org.ua/index.php/journal/article/view/615 |
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| Journal Title: | Ukrainian Chemistry Journal |
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Ukrainian Chemistry Journal| Summary: | A polyelectrolyte complex (PEC) of sodium alginate with polyethyleneimine, loaded with (5 wt.%) inclusion complex (IC) of sulfobutylether β-cyclodextrin with dexamethasone, was formed from aqueous solutions. Dexamethasone (DM) is a medical and veterinary synthetic glucocorticosteroid with anti-inflammatory and immunosuppressive effects, used in the treatment of various diseases. The structure of the obtained compositions was analyzed by X-ray diffraction method, confirming the interaction PEC and IC through both Coulombic forces between the ionic groups of PEC and hydrogen bonding involving the proton-donor and proton-acceptor polar groups of PEC and IC. These findings were supported by pyrolytic mass spectrometry data and differential scanning calorimetry. The decrease in PEC swelling degree further supports the above conclusions. Testing the obtained PEC films for drug release using UV spectrophotometry revealed that the release kinetics were nonlinear and partially dependent on the release medium, indicating their potential as materials for creating polymer matrices with prolonged therapeutic effects. |
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