POLYLECTROLYTE COMPLEX OF SODIUM ALGINATE - POLYETHYLENIMINE WITH THE INCLUSION COMPLEX OF SULFOBUTYL ETHER β-CYCLODEXTRIN – DEXAMETHASONE.
A polyelectrolyte complex (PEC) of sodium alginate with polyethyleneimine, loaded with (5 wt.%) inclusion complex (IC) of sulfobutylether β-cyclodextrin with dexamethasone, was formed from aqueous solutions. Dexamethasone (DM) is a medical and veterinary synthetic glucocorticosteroid with anti-inf...
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| Дата: | 2023 |
|---|---|
| Автори: | , , , , |
| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
V.I.Vernadsky Institute of General and Inorganic Chemistry
2023
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| Онлайн доступ: | https://ucj.org.ua/index.php/journal/article/view/615 |
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| Назва журналу: | Ukrainian Chemistry Journal |
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oai:ojs2.1444248.nisspano.web.hosting-test.net:article-6152024-10-07T12:25:37Z POLYLECTROLYTE COMPLEX OF SODIUM ALGINATE - POLYETHYLENIMINE WITH THE INCLUSION COMPLEX OF SULFOBUTYL ETHER β-CYCLODEXTRIN – DEXAMETHASONE. Kobrina, Larisa Boiko, Valentina Riabov, Serhii Stompel, Volodumir Sinelnikov, Serhii polyelectrolyte complex, inclusion complex, sodium salt of sulfobutyl ether β-cyclodextrin, dexamethasone, polymer matrix, prolonged therapeutic effect. A polyelectrolyte complex (PEC) of sodium alginate with polyethyleneimine, loaded with (5 wt.%) inclusion complex (IC) of sulfobutylether β-cyclodextrin with dexamethasone, was formed from aqueous solutions. Dexamethasone (DM) is a medical and veterinary synthetic glucocorticosteroid with anti-inflammatory and immunosuppressive effects, used in the treatment of various diseases. The structure of the obtained compositions was analyzed by X-ray diffraction method, confirming the interaction PEC and IC through both Coulombic forces between the ionic groups of PEC and hydrogen bonding involving the proton-donor and proton-acceptor polar groups of PEC and IC. These findings were supported by pyrolytic mass spectrometry data and differential scanning calorimetry. The decrease in PEC swelling degree further supports the above conclusions. Testing the obtained PEC films for drug release using UV spectrophotometry revealed that the release kinetics were nonlinear and partially dependent on the release medium, indicating their potential as materials for creating polymer matrices with prolonged therapeutic effects. V.I.Vernadsky Institute of General and Inorganic Chemistry 2023-12-29 Article Article Organic chemistry Органическая xимия Органічна xімія application/pdf https://ucj.org.ua/index.php/journal/article/view/615 10.33609/2708-129X.89.11.2023.64-74 Ukrainian Chemistry Journal; Vol 89 No 11 (2023): Ukrainian Chemistry Journal; 64-74 Украинский химический журнал; Том 89 № 11 (2023): Ukrainian Chemistry Journal; 64-74 Український хімічний журнал; Том 89 № 11 (2023): Український хімічний журнал; 64-74 2708-129X 2708-1281 en https://ucj.org.ua/index.php/journal/article/view/615/310 |
| institution |
Ukrainian Chemistry Journal |
| baseUrl_str |
|
| datestamp_date |
2024-10-07T12:25:37Z |
| collection |
OJS |
| language |
English |
| topic_facet |
polyelectrolyte complex inclusion complex sodium salt of sulfobutyl ether β-cyclodextrin dexamethasone polymer matrix prolonged therapeutic effect. |
| format |
Article |
| author |
Kobrina, Larisa Boiko, Valentina Riabov, Serhii Stompel, Volodumir Sinelnikov, Serhii |
| spellingShingle |
Kobrina, Larisa Boiko, Valentina Riabov, Serhii Stompel, Volodumir Sinelnikov, Serhii POLYLECTROLYTE COMPLEX OF SODIUM ALGINATE - POLYETHYLENIMINE WITH THE INCLUSION COMPLEX OF SULFOBUTYL ETHER β-CYCLODEXTRIN – DEXAMETHASONE. |
| author_facet |
Kobrina, Larisa Boiko, Valentina Riabov, Serhii Stompel, Volodumir Sinelnikov, Serhii |
| author_sort |
Kobrina, Larisa |
| title |
POLYLECTROLYTE COMPLEX OF SODIUM ALGINATE - POLYETHYLENIMINE WITH THE INCLUSION COMPLEX OF SULFOBUTYL ETHER β-CYCLODEXTRIN – DEXAMETHASONE. |
| title_short |
POLYLECTROLYTE COMPLEX OF SODIUM ALGINATE - POLYETHYLENIMINE WITH THE INCLUSION COMPLEX OF SULFOBUTYL ETHER β-CYCLODEXTRIN – DEXAMETHASONE. |
| title_full |
POLYLECTROLYTE COMPLEX OF SODIUM ALGINATE - POLYETHYLENIMINE WITH THE INCLUSION COMPLEX OF SULFOBUTYL ETHER β-CYCLODEXTRIN – DEXAMETHASONE. |
| title_fullStr |
POLYLECTROLYTE COMPLEX OF SODIUM ALGINATE - POLYETHYLENIMINE WITH THE INCLUSION COMPLEX OF SULFOBUTYL ETHER β-CYCLODEXTRIN – DEXAMETHASONE. |
| title_full_unstemmed |
POLYLECTROLYTE COMPLEX OF SODIUM ALGINATE - POLYETHYLENIMINE WITH THE INCLUSION COMPLEX OF SULFOBUTYL ETHER β-CYCLODEXTRIN – DEXAMETHASONE. |
| title_sort |
polylectrolyte complex of sodium alginate - polyethylenimine with the inclusion complex of sulfobutyl ether β-cyclodextrin – dexamethasone. |
| description |
A polyelectrolyte complex (PEC) of sodium alginate with polyethyleneimine, loaded with (5 wt.%) inclusion complex (IC) of sulfobutylether β-cyclodextrin with dexamethasone, was formed from aqueous solutions. Dexamethasone (DM) is a medical and veterinary synthetic glucocorticosteroid with anti-inflammatory and immunosuppressive effects, used in the treatment of various diseases. The structure of the obtained compositions was analyzed by X-ray diffraction method, confirming the interaction PEC and IC through both Coulombic forces between the ionic groups of PEC and hydrogen bonding involving the proton-donor and proton-acceptor polar groups of PEC and IC. These findings were supported by pyrolytic mass spectrometry data and differential scanning calorimetry. The decrease in PEC swelling degree further supports the above conclusions. Testing the obtained PEC films for drug release using UV spectrophotometry revealed that the release kinetics were nonlinear and partially dependent on the release medium, indicating their potential as materials for creating polymer matrices with prolonged therapeutic effects. |
| publisher |
V.I.Vernadsky Institute of General and Inorganic Chemistry |
| publishDate |
2023 |
| url |
https://ucj.org.ua/index.php/journal/article/view/615 |
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2025-09-24T17:43:54Z |
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2025-09-24T17:43:54Z |
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