PREDICTION OF BIOLOGICAL ACTIVITY OF AMINOQUINOLINE DERIVATIVES USING THE ADMET 2.0 WEB RESOURCE

• Дата: 2024
• Автори та афіліації: Svetlana Varenichenko — Associate Professor Department of Pharmacies and Technology of Organic Substances, Ukrainian State Chemical Technology University, Dnipro, Ukraine; Oleg Farat — Department of Pharmacies and Technology of Organic Substances, Ukrainian State Chemical Technology University, Dnipro, Ukraine
• Ключові слова: keywords
• Автори: Varenichenko, Svetlana, Farat, Oleg
• Формат: Стаття
• Мова: Англійська
• Опубліковано: V.I.Vernadsky Institute of General and Inorganic Chemistry 2024
• Онлайн доступ: https://ucj.org.ua/index.php/journal/article/view/629
• Назва журналу: Ukrainian Chemistry Journal

The objective of this study was to predict the pharmacokinetic parameters of 5,6,7,8-tetra­hydroquinoline-3-amine derivatives using the ADMET 2.0 web resource and compare them with 4-aminoquinoline and chloroquine. The tested substances exhibited favorable indicators of intestinal absorption, cleara...