ASYMMETRIC SYNTHESIS OF CHI-CONSTRAINED GLUTAMIC ACIDS AND RELATED COMPOUNDS VIA MICHAEL ADDITION REACTIONS

• Дата: 2024
• Автори: Wzorek, Alicja, Sorochinsky, Alexander, Klika, Karel, Ono, Taizo, Han, Jianlin, Soloshonok, Vadim
• Формат: Стаття
• Мова: English
• Опубліковано: V.I.Vernadsky Institute of General and Inorganic Chemistry 2024
• Онлайн доступ: https://ucj.org.ua/index.php/journal/article/view/685
• Назва журналу: Ukrainian Chemistry Journal

Michael addition reactions involving nucleophilic glycine equivalents and α,β-unsaturated carboxylic acid derivatives offer a concise and generalized methodological approach to synthesizing a family of χ-constrained five-carbon-atom amino acids. These amino acids play a crucial role in de novo pepti...