STRUCTURE FEATURES AND PHARMACOLOGICAL PROPERTIES OF GERMANIUM(IV) COMPLEXES WITH 1-HYDROXYETHANE-1,1-DIPHOSPHONIC ACID

STRUCTURE FEATURES AND PHARMACOLOGICAL PROPERTIES OF GERMANIUM(IV) COMPLEXES WITH 1-HYDROXYETHANE-1,1-DIPHOSPHONIC ACID

  The review article presents the results of systematic research by the authors of a number of heterometals and mixed-ligand 1-hydroxyethane-1,1-diphosphonatogermanates, their structure, biological and pharmacological properties. It was observed, that hexanuclear cyclic complex anions of th...

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Date:2024
Main Authors: Martsynko, Olena, Seifullina, Inna, Finik, Оlena, Tsymbaliuk, Kyrylo
Format: Article
Language:English
Published: V.I.Vernadsky Institute of General and Inorganic Chemistry 2024
Online Access:https://ucj.org.ua/index.php/journal/article/view/688
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Journal Title:Ukrainian Chemistry Journal

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Ukrainian Chemistry Journal
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spelling oai:ojs2.1444248.nisspano.web.hosting-test.net:article-6882025-03-21T18:56:21Z STRUCTURE FEATURES AND PHARMACOLOGICAL PROPERTIES OF GERMANIUM(IV) COMPLEXES WITH 1-HYDROXYETHANE-1,1-DIPHOSPHONIC ACID Martsynko, Olena Seifullina, Inna Finik, Оlena Tsymbaliuk, Kyrylo germanium(IV), 1-hydroxyethane-1,1-diphosphonic (etidronic) acid, nitrogen heterocycles, coordination compounds, biological activity.   The review article presents the results of systematic research by the authors of a number of heterometals and mixed-ligand 1-hydroxyethane-1,1-diphosphonatogermanates, their structure, biological and pharmacological properties. It was observed, that hexanuclear cyclic complex anions of the general composition [Ge6(µ-OH)6-n(µ-O)n(µ-hedp)6](6+n)− were present in the aqueous solutions of investigated compounds. At the same time, the composition and charge of the anion in each compound obtained in the solid state depends on the nature of the cation. They all have a common hexameric structure, with germanium atoms connected in pairs by 1-hydroxyethane-1,1-diphosphonate, hydroxo-, or oxo- and hydroxo-bridges. The coordination polyhedron Ge is a curved octahedron with two six-membered GeO2P2C cycles and an eight-membered bimetallic Ge2O4P2 closing, and each ligand performs a tetradentate tris(chelate)-µ-bridging function. The ratio of formed oxo- and hydroxo-bridges and, as a result, the charge of the anion varies under the influence of cation parameters and electrosta­tic interactions. Acute and chronic toxicity studies proved the safety of 1-hydroxyethane-1,1-diphosphonatogermanates. Complexes show a wide spectrum of pharmacological activity: antihypertensive, antiarrhythmic, hepatoprotective, cerebroprotective etc.The pharmacological and biological activities of 1-hydroxyethane-1,1-diphosphonatogermanates(IV) are ensured by the combined action of all biologically active components, which do not compete but show synergistic action. It was concluded that the preparation of new complexes of germanium(IV) with etidronic acid by chemical modification of their composition is a promising area of research in the field of creating coordination compounds with a wide range of pharmacological effects. V.I.Vernadsky Institute of General and Inorganic Chemistry 2024-10-25 Article Article Inorganic Chemistry Неорганическая химия Неорганічна хімія application/pdf https://ucj.org.ua/index.php/journal/article/view/688 10.33609/2708-129X.90.9.2024.19-30 Ukrainian Chemistry Journal; Vol 90 No 9 (2024): Ukrainian Chemistry Journal; 19-30 Украинский химический журнал; Том 90 № 9 (2024): Ukrainian Chemistry Journal; 19-30 Український хімічний журнал; Том 90 № 9 (2024): Ukrainian Chemistry Journal; 19-30 2708-129X 2708-1281 en https://ucj.org.ua/index.php/journal/article/view/688/342
institution Ukrainian Chemistry Journal
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datestamp_date 2025-03-21T18:56:21Z
collection OJS
language English
topic_facet germanium(IV)
1-hydroxyethane-1,1-diphosphonic (etidronic) acid
nitrogen heterocycles
coordination compounds
biological activity.
format Article
author Martsynko, Olena
Seifullina, Inna
Finik, Оlena
Tsymbaliuk, Kyrylo
spellingShingle Martsynko, Olena
Seifullina, Inna
Finik, Оlena
Tsymbaliuk, Kyrylo
STRUCTURE FEATURES AND PHARMACOLOGICAL PROPERTIES OF GERMANIUM(IV) COMPLEXES WITH 1-HYDROXYETHANE-1,1-DIPHOSPHONIC ACID
author_facet Martsynko, Olena
Seifullina, Inna
Finik, Оlena
Tsymbaliuk, Kyrylo
author_sort Martsynko, Olena
title STRUCTURE FEATURES AND PHARMACOLOGICAL PROPERTIES OF GERMANIUM(IV) COMPLEXES WITH 1-HYDROXYETHANE-1,1-DIPHOSPHONIC ACID
title_short STRUCTURE FEATURES AND PHARMACOLOGICAL PROPERTIES OF GERMANIUM(IV) COMPLEXES WITH 1-HYDROXYETHANE-1,1-DIPHOSPHONIC ACID
title_full STRUCTURE FEATURES AND PHARMACOLOGICAL PROPERTIES OF GERMANIUM(IV) COMPLEXES WITH 1-HYDROXYETHANE-1,1-DIPHOSPHONIC ACID
title_fullStr STRUCTURE FEATURES AND PHARMACOLOGICAL PROPERTIES OF GERMANIUM(IV) COMPLEXES WITH 1-HYDROXYETHANE-1,1-DIPHOSPHONIC ACID
title_full_unstemmed STRUCTURE FEATURES AND PHARMACOLOGICAL PROPERTIES OF GERMANIUM(IV) COMPLEXES WITH 1-HYDROXYETHANE-1,1-DIPHOSPHONIC ACID
title_sort structure features and pharmacological properties of germanium(iv) complexes with 1-hydroxyethane-1,1-diphosphonic acid
description   The review article presents the results of systematic research by the authors of a number of heterometals and mixed-ligand 1-hydroxyethane-1,1-diphosphonatogermanates, their structure, biological and pharmacological properties. It was observed, that hexanuclear cyclic complex anions of the general composition [Ge6(µ-OH)6-n(µ-O)n(µ-hedp)6](6+n)− were present in the aqueous solutions of investigated compounds. At the same time, the composition and charge of the anion in each compound obtained in the solid state depends on the nature of the cation. They all have a common hexameric structure, with germanium atoms connected in pairs by 1-hydroxyethane-1,1-diphosphonate, hydroxo-, or oxo- and hydroxo-bridges. The coordination polyhedron Ge is a curved octahedron with two six-membered GeO2P2C cycles and an eight-membered bimetallic Ge2O4P2 closing, and each ligand performs a tetradentate tris(chelate)-µ-bridging function. The ratio of formed oxo- and hydroxo-bridges and, as a result, the charge of the anion varies under the influence of cation parameters and electrosta­tic interactions. Acute and chronic toxicity studies proved the safety of 1-hydroxyethane-1,1-diphosphonatogermanates. Complexes show a wide spectrum of pharmacological activity: antihypertensive, antiarrhythmic, hepatoprotective, cerebroprotective etc.The pharmacological and biological activities of 1-hydroxyethane-1,1-diphosphonatogermanates(IV) are ensured by the combined action of all biologically active components, which do not compete but show synergistic action. It was concluded that the preparation of new complexes of germanium(IV) with etidronic acid by chemical modification of their composition is a promising area of research in the field of creating coordination compounds with a wide range of pharmacological effects.
publisher V.I.Vernadsky Institute of General and Inorganic Chemistry
publishDate 2024
url https://ucj.org.ua/index.php/journal/article/view/688
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last_indexed 2025-09-24T17:43:58Z
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