HAMARI’S CONTRIBUTION TO THE ASYMMETRIC SYNTHESIS OF TAILOR-MADE AMINO ACIDS

HAMARI’S CONTRIBUTION TO THE ASYMMETRIC SYNTHESIS OF TAILOR-MADE AMINO ACIDS

This article reviews the development of the asymmetric synthesis of tailor-made amino acids conducted at Hamari Chemicals during the 10-year period 2013–2022.The discussion is based on strategies such as direct chiral modification of unprotected amino acids via intermediate formation of Ni(II) compl...

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Збережено в:
Бібліографічні деталі
Дата:2024
Автори: Han, Jianlin, Liu, Hong, Wang, Jiang, Wzorek, Alicja, Sorochinsky, Alexander, Klika, Karel, Ono, Taizo, Moriwaki, Hiroki, Sato, Tatsunori, Kunisuke , Izawa, Konno, Hiroyuki, Soloshonok, Vadim
Формат: Стаття
Мова:English
Опубліковано: V.I.Vernadsky Institute of General and Inorganic Chemistry 2024
Онлайн доступ:https://ucj.org.ua/index.php/journal/article/view/693
Теги: Додати тег
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Назва журналу:Ukrainian Chemistry Journal

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Ukrainian Chemistry Journal
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Резюме:This article reviews the development of the asymmetric synthesis of tailor-made amino acids conducted at Hamari Chemicals during the 10-year period 2013–2022.The discussion is based on strategies such as direct chiral modification of unprotected amino acids via intermediate formation of Ni(II) complexes and elaboration of chiral nucleophilic or electrophilic glycine equivalents. The former approach includes, for example, second-order asymmetric transformation, dynamic kinetic resolution, and inversion of chirality while the latter approach involves construction of the desired amino acid architecture using, for example, alkylation, aldol, Mannich, or Michael addition reactions as well as multistep procedures. Operational convenience, scalability, and practicality of the developed methods are emphasized.

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