HAMARI’S CONTRIBUTION TO THE ASYMMETRIC SYNTHESIS OF TAILOR-MADE AMINO ACIDS(Review)
This article reviews the development of the asymmetric synthesis of tailor-made amino acids conducted at Hamari Chemicals during the 10-year period 2013–2022.The discussion is based on strategies such as direct chiral modification of unprotected amino acids via intermediate formation of Ni(II) compl...
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| Дата: | 2024 |
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| Автори: | , , , , , , , , , , , |
| Формат: | Стаття |
| Мова: | Англійська |
| Опубліковано: |
V.I.Vernadsky Institute of General and Inorganic Chemistry
2024
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| Онлайн доступ: | https://ucj.org.ua/index.php/journal/article/view/693 |
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| Назва журналу: | Ukrainian Chemistry Journal |
Репозитарії
Ukrainian Chemistry Journal| _version_ | 1860506946388361216 |
|---|---|
| author | Han, Jianlin Liu, Hong Wang, Jiang Wzorek, Alicja Sorochinsky, Alexander Klika, Karel Ono, Taizo Moriwaki, Hiroki Sato, Tatsunori Kunisuke , Izawa Konno, Hiroyuki Soloshonok, Vadim |
| author_facet | Han, Jianlin Liu, Hong Wang, Jiang Wzorek, Alicja Sorochinsky, Alexander Klika, Karel Ono, Taizo Moriwaki, Hiroki Sato, Tatsunori Kunisuke , Izawa Konno, Hiroyuki Soloshonok, Vadim |
| author_sort | Han, Jianlin |
| baseUrl_str | https://ucj.org.ua/index.php/journal/oai |
| collection | OJS |
| datestamp_date | 2026-03-23T11:23:46Z |
| description | This article reviews the development of the asymmetric synthesis of tailor-made amino acids conducted at Hamari Chemicals during the 10-year period 2013–2022.The discussion is based on strategies such as direct chiral modification of unprotected amino acids via intermediate formation of Ni(II) complexes and elaboration of chiral nucleophilic or electrophilic glycine equivalents. The former approach includes, for example, second-order asymmetric transformation, dynamic kinetic resolution, and inversion of chirality while the latter approach involves construction of the desired amino acid architecture using, for example, alkylation, aldol, Mannich, or Michael addition reactions as well as multistep procedures. Operational convenience, scalability, and practicality of the developed methods are emphasized. |
| doi_str_mv | 10.33609/2708-129X.90.10.2024.88-134 |
| first_indexed | 2025-09-24T17:43:58Z |
| format | Article |
| id | oai:ojs2.1444248.nisspano.web.hosting-test.net:article-693 |
| institution | Ukrainian Chemistry Journal |
| keywords_txt_mv | keywords |
| language | English |
| last_indexed | 2026-03-23T18:47:18Z |
| publishDate | 2024 |
| publisher | V.I.Vernadsky Institute of General and Inorganic Chemistry |
| record_format | ojs |
| spelling | oai:ojs2.1444248.nisspano.web.hosting-test.net:article-6932026-03-23T11:23:46Z HAMARI’S CONTRIBUTION TO THE ASYMMETRIC SYNTHESIS OF TAILOR-MADE AMINO ACIDS(Review) Han, Jianlin Liu, Hong Wang, Jiang Wzorek, Alicja Sorochinsky, Alexander Klika, Karel Ono, Taizo Moriwaki, Hiroki Sato, Tatsunori Kunisuke , Izawa Konno, Hiroyuki Soloshonok, Vadim tailor-made amino acids; drug design and development; second-order asymmetric transformation; dynamic kinetic resolution; inversion of chirality. This article reviews the development of the asymmetric synthesis of tailor-made amino acids conducted at Hamari Chemicals during the 10-year period 2013–2022.The discussion is based on strategies such as direct chiral modification of unprotected amino acids via intermediate formation of Ni(II) complexes and elaboration of chiral nucleophilic or electrophilic glycine equivalents. The former approach includes, for example, second-order asymmetric transformation, dynamic kinetic resolution, and inversion of chirality while the latter approach involves construction of the desired amino acid architecture using, for example, alkylation, aldol, Mannich, or Michael addition reactions as well as multistep procedures. Operational convenience, scalability, and practicality of the developed methods are emphasized. V.I.Vernadsky Institute of General and Inorganic Chemistry 2024-11-29 Article Article Organic chemistry Органическая xимия Органічна xімія application/pdf https://ucj.org.ua/index.php/journal/article/view/693 10.33609/2708-129X.90.10.2024.88-134 Ukrainian Chemistry Journal; Vol. 90 No. 10 (2024): Ukrainian Chemistry Journal; 88-134 Украинский химический журнал; Том 90 № 10 (2024): Ukrainian Chemistry Journal; 88-134 Український хімічний журнал; Том 90 № 10 (2024): Ukrainian Chemistry Journal; 88-134 2708-129X 2708-1281 en https://ucj.org.ua/index.php/journal/article/view/693/346 |
| spellingShingle | Han, Jianlin Liu, Hong Wang, Jiang Wzorek, Alicja Sorochinsky, Alexander Klika, Karel Ono, Taizo Moriwaki, Hiroki Sato, Tatsunori Kunisuke , Izawa Konno, Hiroyuki Soloshonok, Vadim HAMARI’S CONTRIBUTION TO THE ASYMMETRIC SYNTHESIS OF TAILOR-MADE AMINO ACIDS(Review) |
| title | HAMARI’S CONTRIBUTION TO THE ASYMMETRIC SYNTHESIS OF TAILOR-MADE AMINO ACIDS(Review) |
| title_full | HAMARI’S CONTRIBUTION TO THE ASYMMETRIC SYNTHESIS OF TAILOR-MADE AMINO ACIDS(Review) |
| title_fullStr | HAMARI’S CONTRIBUTION TO THE ASYMMETRIC SYNTHESIS OF TAILOR-MADE AMINO ACIDS(Review) |
| title_full_unstemmed | HAMARI’S CONTRIBUTION TO THE ASYMMETRIC SYNTHESIS OF TAILOR-MADE AMINO ACIDS(Review) |
| title_short | HAMARI’S CONTRIBUTION TO THE ASYMMETRIC SYNTHESIS OF TAILOR-MADE AMINO ACIDS(Review) |
| title_sort | hamari’s contribution to the asymmetric synthesis of tailor-made amino acids(review) |
| topic_facet | tailor-made amino acids drug design and development second-order asymmetric transformation dynamic kinetic resolution inversion of chirality. |
| url | https://ucj.org.ua/index.php/journal/article/view/693 |
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