EFFECTIVE METHOD FOR PRODUCING 2-STYRYLPYRIMIDIN-4(3H)-ONES
A convenient scheme for the synthesis of a series of compounds of (E)-6-R-2-styrylpyrimidin-(4H)-ones by reduction of 2-(2-oxo-2-arylethylidene)-2,3-dihydropyrimidin-4(1H)-ones with sodium borohydride was developed followed by dehydration of the obtained 2-(2-hydroxy-2-arylethyl)pyrimidin-4(3H)-o...
Gespeichert in:
| Datum: | 2025 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | Englisch |
| Veröffentlicht: |
V.I.Vernadsky Institute of General and Inorganic Chemistry
2025
|
| Online Zugang: | https://ucj.org.ua/index.php/journal/article/view/713 |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Назва журналу: | Ukrainian Chemistry Journal |
Institution
Ukrainian Chemistry Journal| _version_ | 1856543843713810432 |
|---|---|
| author | Yavolovskii, Arkadii Grishchuk, Lidiya Pluzhnik-Glagyr, Sergei Kamalov, Gerbert |
| author_facet | Yavolovskii, Arkadii Grishchuk, Lidiya Pluzhnik-Glagyr, Sergei Kamalov, Gerbert |
| author_sort | Yavolovskii, Arkadii |
| baseUrl_str | |
| collection | OJS |
| datestamp_date | 2025-05-07T17:16:24Z |
| description | A convenient scheme for the synthesis of a series of compounds of (E)-6-R-2-styrylpyrimidin-(4H)-ones by reduction of 2-(2-oxo-2-arylethylidene)-2,3-dihydropyrimidin-4(1H)-ones with sodium borohydride was developed followed by dehydration of the obtained 2-(2-hydroxy-2-arylethyl)pyrimidin-4(3H)-ones in orthophosphoric acid at elevated temperature. Two variants of modification of 2-styrylpyrimidin-4(3H)-ones are proposed. Namely, 4-methylbenzosulfonates were synthesized, and it was also established that upon the interaction of (E)-6-methyl-2-styrylpyrimidin-(4H)-one with an equimolecular amount of Br2, the reaction product turned out to be (E)-5-bromo-6-R-2-styrylpyrimidine-(4H)-one. The structure of the synthesized compounds was established using NMR spectroscopy and mass spectrometry. |
| first_indexed | 2025-09-24T17:44:00Z |
| format | Article |
| id | oai:ojs2.1444248.nisspano.web.hosting-test.net:article-713 |
| institution | Ukrainian Chemistry Journal |
| language | English |
| last_indexed | 2025-09-24T17:44:00Z |
| publishDate | 2025 |
| publisher | V.I.Vernadsky Institute of General and Inorganic Chemistry |
| record_format | ojs |
| spelling | oai:ojs2.1444248.nisspano.web.hosting-test.net:article-7132025-05-07T17:16:24Z EFFECTIVE METHOD FOR PRODUCING 2-STYRYLPYRIMIDIN-4(3H)-ONES Yavolovskii, Arkadii Grishchuk, Lidiya Pluzhnik-Glagyr, Sergei Kamalov, Gerbert 2-(2-Oxo-2-arylethylsulfanyl)-pyrimidin-4(3H)-ones, 2-(2-hydroxy-2-arylethyl)pyrimidin-4(3H)-ones, (E)-6-R-2-styrylpyrimidine-(4H)-ones, reduction, dehydration, bromination, synthesis, structure. A convenient scheme for the synthesis of a series of compounds of (E)-6-R-2-styrylpyrimidin-(4H)-ones by reduction of 2-(2-oxo-2-arylethylidene)-2,3-dihydropyrimidin-4(1H)-ones with sodium borohydride was developed followed by dehydration of the obtained 2-(2-hydroxy-2-arylethyl)pyrimidin-4(3H)-ones in orthophosphoric acid at elevated temperature. Two variants of modification of 2-styrylpyrimidin-4(3H)-ones are proposed. Namely, 4-methylbenzosulfonates were synthesized, and it was also established that upon the interaction of (E)-6-methyl-2-styrylpyrimidin-(4H)-one with an equimolecular amount of Br2, the reaction product turned out to be (E)-5-bromo-6-R-2-styrylpyrimidine-(4H)-one. The structure of the synthesized compounds was established using NMR spectroscopy and mass spectrometry. V.I.Vernadsky Institute of General and Inorganic Chemistry 2025-04-25 Article Article Organic chemistry Органическая xимия Органічна xімія application/pdf https://ucj.org.ua/index.php/journal/article/view/713 10.33609/2708-129X.91.3.2025.25-33 Ukrainian Chemistry Journal; Vol. 91 No. 3 (2025): Ukrainian Chemistry Journal; 25-33 Украинский химический журнал; Том 91 № 3 (2025): Ukrainian Chemistry Journal; 25-33 Український хімічний журнал; Том 91 № 3 (2025): Ukrainian Chemistry Journal; 25-33 2708-129X 2708-1281 en https://ucj.org.ua/index.php/journal/article/view/713/361 |
| spellingShingle | Yavolovskii, Arkadii Grishchuk, Lidiya Pluzhnik-Glagyr, Sergei Kamalov, Gerbert EFFECTIVE METHOD FOR PRODUCING 2-STYRYLPYRIMIDIN-4(3H)-ONES |
| title | EFFECTIVE METHOD FOR PRODUCING 2-STYRYLPYRIMIDIN-4(3H)-ONES |
| title_full | EFFECTIVE METHOD FOR PRODUCING 2-STYRYLPYRIMIDIN-4(3H)-ONES |
| title_fullStr | EFFECTIVE METHOD FOR PRODUCING 2-STYRYLPYRIMIDIN-4(3H)-ONES |
| title_full_unstemmed | EFFECTIVE METHOD FOR PRODUCING 2-STYRYLPYRIMIDIN-4(3H)-ONES |
| title_short | EFFECTIVE METHOD FOR PRODUCING 2-STYRYLPYRIMIDIN-4(3H)-ONES |
| title_sort | effective method for producing 2-styrylpyrimidin-4(3h)-ones |
| topic_facet | 2-(2-Oxo-2-arylethylsulfanyl)-pyrimidin-4(3H)-ones 2-(2-hydroxy-2-arylethyl)pyrimidin-4(3H)-ones (E)-6-R-2-styrylpyrimidine-(4H)-ones reduction dehydration bromination synthesis structure. |
| url | https://ucj.org.ua/index.php/journal/article/view/713 |
| work_keys_str_mv | AT yavolovskiiarkadii effectivemethodforproducing2styrylpyrimidin43hones AT grishchuklidiya effectivemethodforproducing2styrylpyrimidin43hones AT pluzhnikglagyrsergei effectivemethodforproducing2styrylpyrimidin43hones AT kamalovgerbert effectivemethodforproducing2styrylpyrimidin43hones |