ENANTIOMER PURIFICATION THROUGH ACHIRAL CHROMATOGRAPHY: INTEGRATING SIMULATED MOVING BED AND SELF-DISPROPORTIONATION OF ENANTIOMERS
Enantiomer purification is a critical process in the pharmaceutical, agrochemical, and food industries, where chiral compounds often exhibit distinct biological activities. Traditional chiral chromatography is effective but costly due to the use of expensive chiral stationary phases. This review art...
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| Дата: | 2025 |
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| Автори: | , , , , , |
| Формат: | Стаття |
| Мова: | Англійська |
| Опубліковано: |
V.I.Vernadsky Institute of General and Inorganic Chemistry
2025
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| Онлайн доступ: | https://ucj.org.ua/index.php/journal/article/view/714 |
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| Назва журналу: | Ukrainian Chemistry Journal |
Репозитарії
Ukrainian Chemistry Journal| _version_ | 1856543843822862336 |
|---|---|
| author | Wzorek, Alicja Klika, Karel Han, Jianlin Sorochinsky, Alexander Ono, Taizo Soloshonok, Vadim |
| author_facet | Wzorek, Alicja Klika, Karel Han, Jianlin Sorochinsky, Alexander Ono, Taizo Soloshonok, Vadim |
| author_sort | Wzorek, Alicja |
| baseUrl_str | |
| collection | OJS |
| datestamp_date | 2025-05-07T17:16:30Z |
| description | Enantiomer purification is a critical process in the pharmaceutical, agrochemical, and food industries, where chiral compounds often exhibit distinct biological activities. Traditional chiral chromatography is effective but costly due to the use of expensive chiral stationary phases. This review article highlights a recent breakthrough in enantiomer purification under entirely achiral conditions. Specifically, it focuses on the convergence of achiral simulated moving bed chromatography and the phenomenon of self-disproportionation of enantiomers (SDE). Experimental validation using scalemic methyl p-tolyl sulfoxide as a model compound enabled the isolation of the excess enantiomer with high purity (99% ee) and a respectable yield (~50%). This innovative process features exceptional productivity (up to 99 grams per liter of column volume per day), reproducibility, and reliability. This breakthrough presents the first practical example of enantiomer purification based on SDE, offering a scalable and economically viable alternative to conventional chiral separations. Given that SDE is an inherent property of all chiral compounds, this innovative approach is anticipated to become the method of choice for practical enantiomer purification in both research and industrial production. |
| first_indexed | 2025-09-24T17:44:00Z |
| format | Article |
| id | oai:ojs2.1444248.nisspano.web.hosting-test.net:article-714 |
| institution | Ukrainian Chemistry Journal |
| language | English |
| last_indexed | 2025-09-24T17:44:00Z |
| publishDate | 2025 |
| publisher | V.I.Vernadsky Institute of General and Inorganic Chemistry |
| record_format | ojs |
| spelling | oai:ojs2.1444248.nisspano.web.hosting-test.net:article-7142025-05-07T17:16:30Z ENANTIOMER PURIFICATION THROUGH ACHIRAL CHROMATOGRAPHY: INTEGRATING SIMULATED MOVING BED AND SELF-DISPROPORTIONATION OF ENANTIOMERS Wzorek, Alicja Klika, Karel Han, Jianlin Sorochinsky, Alexander Ono, Taizo Soloshonok, Vadim Chirality, Enantiomers, Purification, Self-Disproportionation of Enantiomers (SDE), Achiral Chromatography, Simulated Moving Bed Chromatography. Enantiomer purification is a critical process in the pharmaceutical, agrochemical, and food industries, where chiral compounds often exhibit distinct biological activities. Traditional chiral chromatography is effective but costly due to the use of expensive chiral stationary phases. This review article highlights a recent breakthrough in enantiomer purification under entirely achiral conditions. Specifically, it focuses on the convergence of achiral simulated moving bed chromatography and the phenomenon of self-disproportionation of enantiomers (SDE). Experimental validation using scalemic methyl p-tolyl sulfoxide as a model compound enabled the isolation of the excess enantiomer with high purity (99% ee) and a respectable yield (~50%). This innovative process features exceptional productivity (up to 99 grams per liter of column volume per day), reproducibility, and reliability. This breakthrough presents the first practical example of enantiomer purification based on SDE, offering a scalable and economically viable alternative to conventional chiral separations. Given that SDE is an inherent property of all chiral compounds, this innovative approach is anticipated to become the method of choice for practical enantiomer purification in both research and industrial production. V.I.Vernadsky Institute of General and Inorganic Chemistry 2025-04-25 Article Article Organic chemistry Органическая xимия Органічна xімія application/pdf https://ucj.org.ua/index.php/journal/article/view/714 10.33609/2708-129X.91.3.2025.34-48 Ukrainian Chemistry Journal; Vol. 91 No. 3 (2025): Ukrainian Chemistry Journal; 34-48 Украинский химический журнал; Том 91 № 3 (2025): Ukrainian Chemistry Journal; 34-48 Український хімічний журнал; Том 91 № 3 (2025): Ukrainian Chemistry Journal; 34-48 2708-129X 2708-1281 en https://ucj.org.ua/index.php/journal/article/view/714/362 |
| spellingShingle | Wzorek, Alicja Klika, Karel Han, Jianlin Sorochinsky, Alexander Ono, Taizo Soloshonok, Vadim ENANTIOMER PURIFICATION THROUGH ACHIRAL CHROMATOGRAPHY: INTEGRATING SIMULATED MOVING BED AND SELF-DISPROPORTIONATION OF ENANTIOMERS |
| title | ENANTIOMER PURIFICATION THROUGH ACHIRAL CHROMATOGRAPHY: INTEGRATING SIMULATED MOVING BED AND SELF-DISPROPORTIONATION OF ENANTIOMERS |
| title_full | ENANTIOMER PURIFICATION THROUGH ACHIRAL CHROMATOGRAPHY: INTEGRATING SIMULATED MOVING BED AND SELF-DISPROPORTIONATION OF ENANTIOMERS |
| title_fullStr | ENANTIOMER PURIFICATION THROUGH ACHIRAL CHROMATOGRAPHY: INTEGRATING SIMULATED MOVING BED AND SELF-DISPROPORTIONATION OF ENANTIOMERS |
| title_full_unstemmed | ENANTIOMER PURIFICATION THROUGH ACHIRAL CHROMATOGRAPHY: INTEGRATING SIMULATED MOVING BED AND SELF-DISPROPORTIONATION OF ENANTIOMERS |
| title_short | ENANTIOMER PURIFICATION THROUGH ACHIRAL CHROMATOGRAPHY: INTEGRATING SIMULATED MOVING BED AND SELF-DISPROPORTIONATION OF ENANTIOMERS |
| title_sort | enantiomer purification through achiral chromatography: integrating simulated moving bed and self-disproportionation of enantiomers |
| topic_facet | Chirality Enantiomers Purification Self-Disproportionation of Enantiomers (SDE) Achiral Chromatography Simulated Moving Bed Chromatography. |
| url | https://ucj.org.ua/index.php/journal/article/view/714 |
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