MECHANOCHEMICAL SYNTHESIS OF FLUORINE-CONTAINING HETEROCYCLES VIA BALL MILLING(Review)

• Datum: 2025
• Автори та афіліації: Jianlin Han — Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China; Alicja Wzorek — Institute of Chemistry, Jan Kochanowski University in Kielce, Uniwersytecka 7, 25-406 Kielce, Poland; Taizo Ono — National Institute of Advanced Industrial Science and Technology, 463-8560, Nagoya, Japan; Karel Klika — Molecular Structure Analysis, German Cancer Research Center (DKFZ), ImNeuenheimer Feld 280, 69120 Heidelberg, Germany; Vadim Soloshonok — University of Basque Country
• Ключові слова: keywords
• Hauptverfasser: Han, Jianlin, Wzorek, Alicja, Ono, Taizo, Klika, Karel, Soloshonok, Vadim
• Format: Artikel
• Sprache: Englisch
• Veröffentlicht: V.I.Vernadsky Institute of General and Inorganic Chemistry 2025
• Online Zugang: https://ucj.org.ua/index.php/journal/article/view/738
• Назва журналу: Ukrainian Chemistry Journal

Fluorine-containing heterocycles play a crucial role in the pharmaceutical, agrochemical, and materials industries. The pursuit of effective and sustainable synthesis methods has driven the development of mechanochemistry as a solvent-free, energy-efficient alternative to conventional chemical transformations. Among these approaches, ball milling has emerged as a particularly promising technique for facilitating chemical reactions. This review covers key achievements over the past decade in the mechanochemical synthesis of fluorinated heterocyclic compounds for bimolecular, trimolecular, and tetramolecular reactions as well as transformations classified as peripheral functionalization of the heterocyclic framework. This work serves as a valuable resource for researchers and practitioners seeking to develop sustainable and efficient catalytic systems for fluorinated heterocyclic synthesis.