MECHANOCHEMICAL SYNTHESIS OF FLUORINE-CONTAINING HETEROCYCLES VIA BALL MILLING(Review)
Fluorine-containing heterocycles play a crucial role in the pharmaceutical, agrochemical, and materials industries. The pursuit of effective and sustainable synthesis methods has driven the development of mechanochemistry as a solvent-free, energy-efficient alternative to conventional chemical trans...
Gespeichert in:
| Datum: | 2025 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | Englisch |
| Veröffentlicht: |
V.I.Vernadsky Institute of General and Inorganic Chemistry
2025
|
| Online Zugang: | https://ucj.org.ua/index.php/journal/article/view/738 |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Назва журналу: | Ukrainian Chemistry Journal |
Institution
Ukrainian Chemistry Journal| _version_ | 1860506952490024960 |
|---|---|
| author | Han, Jianlin Wzorek, Alicja Ono, Taizo Klika, Karel Soloshonok, Vadim |
| author_facet | Han, Jianlin Wzorek, Alicja Ono, Taizo Klika, Karel Soloshonok, Vadim |
| author_sort | Han, Jianlin |
| baseUrl_str | https://ucj.org.ua/index.php/journal/oai |
| collection | OJS |
| datestamp_date | 2026-03-23T11:20:23Z |
| description | Fluorine-containing heterocycles play a crucial role in the pharmaceutical, agrochemical, and materials industries. The pursuit of effective and sustainable synthesis methods has driven the development of mechanochemistry as a solvent-free, energy-efficient alternative to conventional chemical transformations. Among these approaches, ball milling has emerged as a particularly promising technique for facilitating chemical reactions. This review covers key achievements over the past decade in the mechanochemical synthesis of fluorinated heterocyclic compounds for bimolecular, trimolecular, and tetramolecular reactions as well as transformations classified as peripheral functionalization of the heterocyclic framework. This work serves as a valuable resource for researchers and practitioners seeking to develop sustainable and efficient catalytic systems for fluorinated heterocyclic synthesis. |
| doi_str_mv | 10.33609/2708-129X.91.7.2025.35-55 |
| first_indexed | 2025-10-23T01:32:48Z |
| format | Article |
| id | oai:ojs2.1444248.nisspano.web.hosting-test.net:article-738 |
| institution | Ukrainian Chemistry Journal |
| keywords_txt_mv | keywords |
| language | English |
| last_indexed | 2026-03-23T18:47:20Z |
| publishDate | 2025 |
| publisher | V.I.Vernadsky Institute of General and Inorganic Chemistry |
| record_format | ojs |
| spelling | oai:ojs2.1444248.nisspano.web.hosting-test.net:article-7382026-03-23T11:20:23Z MECHANOCHEMICAL SYNTHESIS OF FLUORINE-CONTAINING HETEROCYCLES VIA BALL MILLING(Review) Han, Jianlin Wzorek, Alicja Ono, Taizo Klika, Karel Soloshonok, Vadim Fluorine, Heterocyclic Compounds, Fluorinated Pharmaceuticals, Mechanochemistry, Ball Milling, Green Chemistry, Sustainable Synthesis. Fluorine-containing heterocycles play a crucial role in the pharmaceutical, agrochemical, and materials industries. The pursuit of effective and sustainable synthesis methods has driven the development of mechanochemistry as a solvent-free, energy-efficient alternative to conventional chemical transformations. Among these approaches, ball milling has emerged as a particularly promising technique for facilitating chemical reactions. This review covers key achievements over the past decade in the mechanochemical synthesis of fluorinated heterocyclic compounds for bimolecular, trimolecular, and tetramolecular reactions as well as transformations classified as peripheral functionalization of the heterocyclic framework. This work serves as a valuable resource for researchers and practitioners seeking to develop sustainable and efficient catalytic systems for fluorinated heterocyclic synthesis. V.I.Vernadsky Institute of General and Inorganic Chemistry 2025-08-25 Article Article Organic chemistry Органическая xимия Органічна xімія application/pdf https://ucj.org.ua/index.php/journal/article/view/738 10.33609/2708-129X.91.7.2025.35-55 Ukrainian Chemistry Journal; Vol. 91 No. 7 (2025): Ukrainian Chemistry Journal; 35-55 Украинский химический журнал; Том 91 № 7 (2025): Ukrainian Chemistry Journal; 35-55 Український хімічний журнал; Том 91 № 7 (2025): Ukrainian Chemistry Journal; 35-55 2708-129X 2708-1281 en https://ucj.org.ua/index.php/journal/article/view/738/376 |
| spellingShingle | Han, Jianlin Wzorek, Alicja Ono, Taizo Klika, Karel Soloshonok, Vadim MECHANOCHEMICAL SYNTHESIS OF FLUORINE-CONTAINING HETEROCYCLES VIA BALL MILLING(Review) |
| title | MECHANOCHEMICAL SYNTHESIS OF FLUORINE-CONTAINING HETEROCYCLES VIA BALL MILLING(Review) |
| title_full | MECHANOCHEMICAL SYNTHESIS OF FLUORINE-CONTAINING HETEROCYCLES VIA BALL MILLING(Review) |
| title_fullStr | MECHANOCHEMICAL SYNTHESIS OF FLUORINE-CONTAINING HETEROCYCLES VIA BALL MILLING(Review) |
| title_full_unstemmed | MECHANOCHEMICAL SYNTHESIS OF FLUORINE-CONTAINING HETEROCYCLES VIA BALL MILLING(Review) |
| title_short | MECHANOCHEMICAL SYNTHESIS OF FLUORINE-CONTAINING HETEROCYCLES VIA BALL MILLING(Review) |
| title_sort | mechanochemical synthesis of fluorine-containing heterocycles via ball milling(review) |
| topic_facet | Fluorine Heterocyclic Compounds Fluorinated Pharmaceuticals Mechanochemistry Ball Milling Green Chemistry Sustainable Synthesis. |
| url | https://ucj.org.ua/index.php/journal/article/view/738 |
| work_keys_str_mv | AT hanjianlin mechanochemicalsynthesisoffluorinecontainingheterocyclesviaballmillingreview AT wzorekalicja mechanochemicalsynthesisoffluorinecontainingheterocyclesviaballmillingreview AT onotaizo mechanochemicalsynthesisoffluorinecontainingheterocyclesviaballmillingreview AT klikakarel mechanochemicalsynthesisoffluorinecontainingheterocyclesviaballmillingreview AT soloshonokvadim mechanochemicalsynthesisoffluorinecontainingheterocyclesviaballmillingreview |