OPTIMIZATION OF SYNTHESIS CONDITIONS OF BIOCOMPATIBLE COLLOID SOLUTIONS OF COPPER METAL PARTICLES
The work presents a comprehensive selection of conditions for the synthesis of nanosized Copper particles in an aqueous oxidizing environment using a biocompatible amino acid – L-Сysteine as a stabilizer, a reducing agent – sodium tetraborate, and the application of the method of mathematical experi...
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| Дата: | 2025 |
|---|---|
| Автор: | |
| Формат: | Стаття |
| Мова: | Англійська |
| Опубліковано: |
V.I.Vernadsky Institute of General and Inorganic Chemistry
2025
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| Онлайн доступ: | https://ucj.org.ua/index.php/journal/article/view/753 |
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| Назва журналу: | Ukrainian Chemistry Journal |
Репозитарії
Ukrainian Chemistry Journal| _version_ | 1859471888449798144 |
|---|---|
| author | Krupko, Olena |
| author_facet | Krupko, Olena |
| author_sort | Krupko, Olena |
| baseUrl_str | |
| collection | OJS |
| datestamp_date | 2026-02-25T17:20:41Z |
| description | The work presents a comprehensive selection of conditions for the synthesis of nanosized Copper particles in an aqueous oxidizing environment using a biocompatible amino acid – L-Сysteine as a stabilizer, a reducing agent – sodium tetraborate, and the application of the method of mathematical experimental planning the Scheffe method.
The use of the mathematical planning method made it possible to predict the additive effect of the ratio between precursors in the studied medium on the value of the optical absorption edge of the obtained colloidal solutions of copper nanoparticles, their stability over time and the effect on test cultures of microorganisms P.aeruginosa, C.albicans, B.subtilitis.
The ratio between the starting reagents that lead to the formation of stable colloidal solutions of copper nanoparticles at pH=6 and temperature of 20°C in an oxidizing reaction medium has been established.
A mathematical model was constructed in the form of a projection onto the plane of an equilateral triangle of the dependence of the value of the optical absorption edge of colloidal solutions of metallic copper nanoparticles on the ratio between the precursors. A mathematical equation was obtained – a fourth-degree polynomial that describes the dependence of the value of the optical absorption edge of colloidal solutions of copper nanoparticles on the ratio between three independent variables – crystal-forming components of time-stable particles in the reaction medium.
The antibacterial activities of a series of test solutions were investigated by the micromethod of serial dilutions in accordance with the procedures of the European Committee for Susceptibility Testing against reference strains of bacteria (P.aeruginosa, C.albicans, B.subtilitis.). Using the Scheffe mathematical model, the concentration regions and ratios between the components of the studied system were determined, which had the highest impact on the action of test cultures of microorganisms. |
| first_indexed | 2026-03-12T15:49:41Z |
| format | Article |
| id | oai:ojs2.1444248.nisspano.web.hosting-test.net:article-753 |
| institution | Ukrainian Chemistry Journal |
| keywords_txt_mv | keywords |
| language | English |
| last_indexed | 2026-03-12T15:49:41Z |
| publishDate | 2025 |
| publisher | V.I.Vernadsky Institute of General and Inorganic Chemistry |
| record_format | ojs |
| spelling | oai:ojs2.1444248.nisspano.web.hosting-test.net:article-7532026-02-25T17:20:41Z OPTIMIZATION OF SYNTHESIS CONDITIONS OF BIOCOMPATIBLE COLLOID SOLUTIONS OF COPPER METAL PARTICLES Krupko, Olena nanoparticles, optical indicators, copper, microorganisms P.aeruginosa, C.albicans, B.subtilitis. The work presents a comprehensive selection of conditions for the synthesis of nanosized Copper particles in an aqueous oxidizing environment using a biocompatible amino acid – L-Сysteine as a stabilizer, a reducing agent – sodium tetraborate, and the application of the method of mathematical experimental planning the Scheffe method. The use of the mathematical planning method made it possible to predict the additive effect of the ratio between precursors in the studied medium on the value of the optical absorption edge of the obtained colloidal solutions of copper nanoparticles, their stability over time and the effect on test cultures of microorganisms P.aeruginosa, C.albicans, B.subtilitis. The ratio between the starting reagents that lead to the formation of stable colloidal solutions of copper nanoparticles at pH=6 and temperature of 20°C in an oxidizing reaction medium has been established. A mathematical model was constructed in the form of a projection onto the plane of an equilateral triangle of the dependence of the value of the optical absorption edge of colloidal solutions of metallic copper nanoparticles on the ratio between the precursors. A mathematical equation was obtained – a fourth-degree polynomial that describes the dependence of the value of the optical absorption edge of colloidal solutions of copper nanoparticles on the ratio between three independent variables – crystal-forming components of time-stable particles in the reaction medium. The antibacterial activities of a series of test solutions were investigated by the micromethod of serial dilutions in accordance with the procedures of the European Committee for Susceptibility Testing against reference strains of bacteria (P.aeruginosa, C.albicans, B.subtilitis.). Using the Scheffe mathematical model, the concentration regions and ratios between the components of the studied system were determined, which had the highest impact on the action of test cultures of microorganisms. V.I.Vernadsky Institute of General and Inorganic Chemistry 2025-11-25 Article Article Inorganic Chemistry Неорганическая химия Неорганічна хімія application/pdf https://ucj.org.ua/index.php/journal/article/view/753 10.33609/2708-129X.91.10.2025.16-26 Ukrainian Chemistry Journal; Vol. 91 No. 10 (2025): Ukrainian Chemistry Journal; 16-26 Украинский химический журнал; Том 91 № 10 (2025): Ukrainian Chemistry Journal; 16-26 Український хімічний журнал; Том 91 № 10 (2025): Ukrainian Chemistry Journal; 16-26 2708-129X 2708-1281 en https://ucj.org.ua/index.php/journal/article/view/753/388 |
| spellingShingle | Krupko, Olena OPTIMIZATION OF SYNTHESIS CONDITIONS OF BIOCOMPATIBLE COLLOID SOLUTIONS OF COPPER METAL PARTICLES |
| title | OPTIMIZATION OF SYNTHESIS CONDITIONS OF BIOCOMPATIBLE COLLOID SOLUTIONS OF COPPER METAL PARTICLES |
| title_full | OPTIMIZATION OF SYNTHESIS CONDITIONS OF BIOCOMPATIBLE COLLOID SOLUTIONS OF COPPER METAL PARTICLES |
| title_fullStr | OPTIMIZATION OF SYNTHESIS CONDITIONS OF BIOCOMPATIBLE COLLOID SOLUTIONS OF COPPER METAL PARTICLES |
| title_full_unstemmed | OPTIMIZATION OF SYNTHESIS CONDITIONS OF BIOCOMPATIBLE COLLOID SOLUTIONS OF COPPER METAL PARTICLES |
| title_short | OPTIMIZATION OF SYNTHESIS CONDITIONS OF BIOCOMPATIBLE COLLOID SOLUTIONS OF COPPER METAL PARTICLES |
| title_sort | optimization of synthesis conditions of biocompatible colloid solutions of copper metal particles |
| topic_facet | nanoparticles optical indicators copper microorganisms P.aeruginosa C.albicans B.subtilitis. |
| url | https://ucj.org.ua/index.php/journal/article/view/753 |
| work_keys_str_mv | AT krupkoolena optimizationofsynthesisconditionsofbiocompatiblecolloidsolutionsofcoppermetalparticles |