ELECTROCHEMICAL SYNTHESIS OF FLUORINATED HETEROCYCLIC COMPOUNDS(Review)

• Date: 2025
• Author Affiliations: Alicja Wzorek — Institute of Chemistry, Jan Kochanowski University in Kielce, Uniwersytecka 7, 25-406 Kielce, Poland; Taizo Ono — National Institute of Advanced Industrial Science and Technology, 463-8560, Nagoya, Japan; Daniel Baecker — Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Freie Universität Berlin, Königin-Luise-Straße 2+4, 14195 Berlin, Germany; Wei Zhang — Department of Chemistry, University of Massachusetts Boston, Boston MA 02125, Unites States;; Vadim Soloshonok — University of Basque Country
• Keywords: keywords
• Main Authors: Wzorek, Alicja, Ono, Taizo, Baecker, Daniel, Zhang, Wei, Soloshonok, Vadim
• Format: Article
• Language: English
• Published: V.I.Vernadsky Institute of General and Inorganic Chemistry 2025
• Online Access: https://ucj.org.ua/index.php/journal/article/view/757
• Journal Title: Ukrainian Chemistry Journal

Fluorine-containing heterocycles play a crucial role in the pharmaceutical, agrochemical, and materials industries. The pursuit of effective and sustainable synthesis methods has dri­ven the development of electrochemistry as a compelling alternative to conventional chemical transformations. Among these approaches, electrochemistry has emerged as a particularly promising technique for orchestrating multibond-forming processes under mild, environmentally benign conditions. This review highlights key advances over the past decade in the electrochemical synthesis of fluorinated heterocyclic compounds, encompassing bimolecular, trimolecular, and tetramolecular reactions. Emphasis is placed on multicomponent cascade strategies, radical-mediated couplings, and oxidant-free cyclizations that afford broad functional group tolerance and fluorine incorporation flexibility. Collectively, this work serves as a resource for researchers developing next-generation sustainable synthetic platforms tailored to fluorinated heterocycles with diverse structural and biological profiles.