ELECTROCHEMICAL SYNTHESIS OF FLUORINATED HETEROCYCLIC COMPOUNDS
Fluorine-containing heterocycles play a crucial role in the pharmaceutical, agrochemical, and materials industries. The pursuit of effective and sustainable synthesis methods has driven the development of electrochemistry as a compelling alternative to conventional chemical transformations. Among t...
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| Datum: | 2025 |
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| Format: | Artikel |
| Sprache: | Englisch |
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V.I.Vernadsky Institute of General and Inorganic Chemistry
2025
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| Online Zugang: | https://ucj.org.ua/index.php/journal/article/view/757 |
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| Назва журналу: | Ukrainian Chemistry Journal |
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Ukrainian Chemistry Journal| _version_ | 1859471888435118080 |
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| author | Wzorek, Alicja Ono, Taizo Baecker, Daniel Zhang, Wei Soloshonok, Vadim |
| author_facet | Wzorek, Alicja Ono, Taizo Baecker, Daniel Zhang, Wei Soloshonok, Vadim |
| author_sort | Wzorek, Alicja |
| baseUrl_str | |
| collection | OJS |
| datestamp_date | 2026-03-09T13:19:17Z |
| description | Fluorine-containing heterocycles play a crucial role in the pharmaceutical, agrochemical, and materials industries. The pursuit of effective and sustainable synthesis methods has driven the development of electrochemistry as a compelling alternative to conventional chemical transformations. Among these approaches, electrochemistry has emerged as a particularly promising technique for orchestrating multibond-forming processes under mild, environmentally benign conditions. This review highlights key advances over the past decade in the electrochemical synthesis of fluorinated heterocyclic compounds, encompassing bimolecular, trimolecular, and tetramolecular reactions. Emphasis is placed on multicomponent cascade strategies, radical-mediated couplings, and oxidant-free cyclizations that afford broad functional group tolerance and fluorine incorporation flexibility. Collectively, this work serves as a resource for researchers developing next-generation sustainable synthetic platforms tailored to fluorinated heterocycles with diverse structural and biological profiles. |
| first_indexed | 2026-03-12T15:49:41Z |
| format | Article |
| id | oai:ojs2.1444248.nisspano.web.hosting-test.net:article-757 |
| institution | Ukrainian Chemistry Journal |
| keywords_txt_mv | keywords |
| language | English |
| last_indexed | 2026-03-12T15:49:41Z |
| publishDate | 2025 |
| publisher | V.I.Vernadsky Institute of General and Inorganic Chemistry |
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| spelling | oai:ojs2.1444248.nisspano.web.hosting-test.net:article-7572026-03-09T13:19:17Z ELECTROCHEMICAL SYNTHESIS OF FLUORINATED HETEROCYCLIC COMPOUNDS Wzorek, Alicja Ono, Taizo Baecker, Daniel Zhang, Wei Soloshonok, Vadim Electrochemistry, Heterocyclic Compounds, Fluorine, Fluorinated Pharmaceuticals, Green Chemistry, Sustainable Synthesis. Fluorine-containing heterocycles play a crucial role in the pharmaceutical, agrochemical, and materials industries. The pursuit of effective and sustainable synthesis methods has driven the development of electrochemistry as a compelling alternative to conventional chemical transformations. Among these approaches, electrochemistry has emerged as a particularly promising technique for orchestrating multibond-forming processes under mild, environmentally benign conditions. This review highlights key advances over the past decade in the electrochemical synthesis of fluorinated heterocyclic compounds, encompassing bimolecular, trimolecular, and tetramolecular reactions. Emphasis is placed on multicomponent cascade strategies, radical-mediated couplings, and oxidant-free cyclizations that afford broad functional group tolerance and fluorine incorporation flexibility. Collectively, this work serves as a resource for researchers developing next-generation sustainable synthetic platforms tailored to fluorinated heterocycles with diverse structural and biological profiles. V.I.Vernadsky Institute of General and Inorganic Chemistry 2025-12-25 Article Article Physical chemistry Физическая xимия Фізична xімія application/pdf https://ucj.org.ua/index.php/journal/article/view/757 10.33609/2708-129X.91.11.2025.35-62 Ukrainian Chemistry Journal; Vol. 91 No. 11 (2025): Ukrainian Chemistry Journal; 35-62 Украинский химический журнал; Том 91 № 11 (2025): Ukrainian Chemistry Journal; 35-62 Український хімічний журнал; Том 91 № 11 (2025): Ukrainian Chemistry Journal; 35-62 2708-129X 2708-1281 en https://ucj.org.ua/index.php/journal/article/view/757/392 |
| spellingShingle | Wzorek, Alicja Ono, Taizo Baecker, Daniel Zhang, Wei Soloshonok, Vadim ELECTROCHEMICAL SYNTHESIS OF FLUORINATED HETEROCYCLIC COMPOUNDS |
| title | ELECTROCHEMICAL SYNTHESIS OF FLUORINATED HETEROCYCLIC COMPOUNDS |
| title_full | ELECTROCHEMICAL SYNTHESIS OF FLUORINATED HETEROCYCLIC COMPOUNDS |
| title_fullStr | ELECTROCHEMICAL SYNTHESIS OF FLUORINATED HETEROCYCLIC COMPOUNDS |
| title_full_unstemmed | ELECTROCHEMICAL SYNTHESIS OF FLUORINATED HETEROCYCLIC COMPOUNDS |
| title_short | ELECTROCHEMICAL SYNTHESIS OF FLUORINATED HETEROCYCLIC COMPOUNDS |
| title_sort | electrochemical synthesis of fluorinated heterocyclic compounds |
| topic_facet | Electrochemistry Heterocyclic Compounds Fluorine Fluorinated Pharmaceuticals Green Chemistry Sustainable Synthesis. |
| url | https://ucj.org.ua/index.php/journal/article/view/757 |
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