ENANTIOSELECTIVE CATALYSIS FOR THE SYNTHESIS OF 1-SUBSTITUTED-2,2,2-TRIFLUOROETHYLAMINES(Review)

• Date: 2026
• Author Affiliations: Alicja Wzorek — Institute of Chemistry, Jan Kochanowski University in Kielce, Uniwersytecka 7, 25-406 Kielce, Poland; Taizo Ono — National Institute of Advanced Industrial Science and Technology, 463-8560, Nagoya, Japan; Daniel Baecker — Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Freie Universität Berlin, Königin-Luise-Straße 2+4, 14195 Berlin, Germany; Wei Zhang — Department of Chemistry, University of Massachusetts Boston, Boston MA 02125, Unites States;; Vadim Soloshonok — University of Basque Country
• Keywords: keywords
• Main Authors: Wzorek, Alicja, Ono, Taizo, Baecker, Daniel, Zhang, Wei, Soloshonok, Vadim
• Format: Article
• Language: English
• Published: V.I.Vernadsky Institute of General and Inorganic Chemistry 2026
• Online Access: https://ucj.org.ua/index.php/journal/article/view/761
• Journal Title: Ukrainian Chemistry Journal

1-Substituted-2,2,2-trifluoroethylamines have emerged as structurally distinct and pharmacologically potent motifs in modern drug design, contributing to enhanced metabolic stability, target selectivity, and bioactivity across various therapeutic classes. This review provides a comprehensive account...