ПОЛІАКРЛИЛАМІДНІ МАТРИЦI НА ОСНОВІ β-ЦИКЛОДЕКСТРИНВМІСНОГО ПСЕВДОРОТАКСАНУ ДЛЯ ПРОЛОНГОВАНОГО ВИВІЛЬНЕННЯ ЛІКАРСЬКИХ ПРЕПАРАТІВ: СИНТЕЗ ТА ВЛАСТИВОСТІ

• Дата: 2019
• Автори: Kobrina, Larisa, Boiko, Valentina, Riabov, Serhii, Orel, Lydmila, Sinelnikov, Serhii, Stompel, Volodumir
• Формат: Стаття
• Мова: English
• Опубліковано: V.I.Vernadsky Institute of General and Inorganic Chemistry 2019
• Онлайн доступ: https://ucj.org.ua/index.php/journal/article/view/94
• Назва журналу: Ukrainian Chemistry Journal

Formation and studying of different inclusion complexes, which could be attributed to the supra-molecular structures, are still remaining among an actual topics in the modern polymer chemistry. The ability of cyclodextrins to selectively interact with a range of their size complementary molecules makes them promising objects for supramolecular chemis-try. Therefore, we obtained polymer matrices involv-ing acrylamide and methylene-bis-acrylamide with different content of pseudorotaxane based on β-cyc-lodextrin and polyoxypropylenedimethacrylate and confirmed their structures by different techniques (FTIR-spectroscopy, DSC and X-ray analysis). The presence of pseudorotaxane in polymer matrices was proved by monitoring β-cyclodextrin’s bands stret-ching vibration (FTIR method). When analyzing X-ray profiles of polymer matrices with different con-tent of pseudorotaxane, we found that the influence of pseudorotaxane is insignificant at its content of 5 and 8 % wt. In addition, the study of pseudoro-taxane effect on the kinetics of drugs release reve-aled that the introduction of 10 wt.% of pseudo-rotaxane into the polymer matrices appreciably de-celerates desorption of drugs and, thus this content being considered as an optimal one for this purpose. Also the polymer matrices’ structure was studied by the pyrolysis mass spectrometry method. It has been determined the temperature decomposition, rate of total ion current, probable composition of ion frag-ments of samples and intensity of their isolation in the mass spectra of polyacrylamide with different content of pseudorotaxane during pyrolysis. Thus, the results obtained can be explained by the for-mation of specific intermolecular bonds emerged between pseudorotaxane fragments and chains of po-lymer matrice.