Синтез N-ацилсульфонамідів: від загальновідомих реакцій ацилювання до сучасних каталітичних і сталих методів
N-Acyl sulfonamides are widely used bioisosteres of carboxylic acids, valued for their favorable physicochemical and pharmacokinetic properties as well as their frequent occurrence in drug-like molecules. This review summarizes the principal synthetic approaches to these motifs, covering both establ...
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| Date: | 2025 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
| Published: |
V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine
2025
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| Subjects: | |
| Online Access: | https://bioorganica.com.ua/index.php/journal/article/view/103 |
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| Journal Title: | Ukrainica Bioorganica Acta |
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Ukrainica Bioorganica Acta| Summary: | N-Acyl sulfonamides are widely used bioisosteres of carboxylic acids, valued for their favorable physicochemical and pharmacokinetic properties as well as their frequent occurrence in drug-like molecules. This review summarizes the principal synthetic approaches to these motifs, covering both established and emerging methodologies, with emphasis on catalytic, green, and operationally simple approaches. Common strategies include direct N-acylation of sulfonamides and N-sulfonylation of carboxamides, as well as transformations employing sulfonyl azides, sulfonyl isocyanates, and related multicomponent processes. Recent developments, such as recyclable heterogeneous catalysts, solvent-free and aqueous conditions, carbonylative and photocatalytic S-N couplings, and mild transition-metal-mediated reactions highlight simplicity and sustainability. Collectively these advances provide an adaptable and efficient synthetic toolbox for accessing diverse N-acyl sulfonamides relevant to modern organic and medicinal chemistry. |
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