Хімія дифлуорометиленфосфонатів: історія, сучасний стан і перспективи

Difluoromethylene phosphonates are non-hydrolyzable bioisosteres of phosphates. They have proven their efficiency as inhibitors of the enzymes that specialize in utilizing these essential biogenic molecules. Difluoromethylene phosphonates show a broad spectrum of biological activity and are used as...

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Збережено в:
Бібліографічні деталі
Дата:2022
Автори: Shevchuk, Mykhailo V., Röschenthaler, Gerd-Volker
Формат: Стаття
Мова:English
Опубліковано: V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine 2022
Теми:
Онлайн доступ:https://bioorganica.com.ua/index.php/journal/article/view/12
Теги: Додати тег
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Назва журналу:Ukrainica Bioorganica Acta

Репозитарії

Ukrainica Bioorganica Acta
Опис
Резюме:Difluoromethylene phosphonates are non-hydrolyzable bioisosteres of phosphates. They have proven their efficiency as inhibitors of the enzymes that specialize in utilizing these essential biogenic molecules. Difluoromethylene phosphonates show a broad spectrum of biological activity and are used as molecular tools to study enzymes and enzyme-substrate interactions. In this review, we briefly summarize the importance of difluoromethylene phosphonates as a distinct class of synthetic phosphonates resulting from multidisciplinary efforts of the organophosphorus, organofluorine, and bioorganic research communities. We outline the development of the synthetic chemistry of difluoromethylene phosphonates from the historical perspective, discuss the most recent trends in the field, and highlight the existing challenges and unsolved questions