Синтез нових 1-гідроксі-1,1-бісфосфонових кислот
A synthetic method for the preparation of 1-hydroxyalkyl-1,1-bisphosphonic and 1-hydroxycycloalkyl-1,1-bisphosphonic acids, commonly known as dronic acids, has been developed. These compounds were obtained through the formation of the corresponding silyl derivatives at key stages of the synthesis. T...
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| Date: | 2025 |
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| Main Authors: | , , |
| Format: | Article |
| Language: | English |
| Published: |
V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine
2025
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| Subjects: | |
| Online Access: | https://bioorganica.com.ua/index.php/journal/article/view/123 |
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| Journal Title: | Ukrainica Bioorganica Acta |
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Ukrainica Bioorganica Acta| Summary: | A synthetic method for the preparation of 1-hydroxyalkyl-1,1-bisphosphonic and 1-hydroxycycloalkyl-1,1-bisphosphonic acids, commonly known as dronic acids, has been developed. These compounds were obtained through the formation of the corresponding silyl derivatives at key stages of the synthesis. The developed method provides a simple and convenient approach for the preparation of hydroxybisphosphonates. The resulting compounds are promising substances with potential biological activity |
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