Синтез нових 1-гідроксі-1,1-бісфосфонових кислот

• Date: 2025
• Author Affiliations: Anastasiia O. Kolodiazhna — V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, Kyiv, Ukraine; Dmytro V. Prysiazhnuk — V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, Kyiv, Ukraine; Serhiy Yu. Sheiko — V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, Kyiv, Ukraine
• Keywords: keywords
• Main Authors: Kolodiazhna, Anastasiia O., Prysiazhnuk, Dmytro V., Sheiko, Serhiy Yu.
• Format: Article
• Language: English
• Published: V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine 2025
• Subjects: біcфосфонові кислоти; дронові кислоти; реакція Арбузова; гідроксибісфосфонати
• Online Access: https://bioorganica.com.ua/index.php/journal/article/view/123
• Journal Title: Ukrainica Bioorganica Acta

A synthetic method for the preparation of 1-hydroxyalkyl-1,1-bisphosphonic and 1-hydroxycycloalkyl-1,1-bisphosphonic acids, commonly known as dronic acids, has been developed. These compounds were obtained through the formation of the corresponding silyl derivatives at key stages of the synthesis. T...