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Синтез нових α-трифлуорометилзаміщених циклобутанових будівельних блоків

Синтез нових α-трифлуорометилзаміщених циклобутанових будівельних блоків

Four new cyclobutane-containing building blocks were synthesized on a multigram scale starting from 3-methylene-1-(trifluoromethyl)cyclobutane-1-carbonitrile and 3-methylene-1-(trifluoromethyl)cyclobutane-1-carboxylic acid. The synthesized compounds contain trifluoromethyl group near the functional...

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Bibliographic Details
Main Authors: Homon, Anton A., Shynder, Lada, Hryshchuk, Oleksandr V., Grygorenko, Oleksandr O., Kondratov, Ivan S.
Format: Article
Language:English
Published: V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine 2022
Subjects:
cyclobutane
trifluoromethyl
building blocks
Curtius rearrangement
fluorination
циклобутан
трифторометил
будівельні блоки
перегрупування Курціуса
фторування
Online Access:https://bioorganica.com.ua/index.php/journal/article/view/15
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Summary:Four new cyclobutane-containing building blocks were synthesized on a multigram scale starting from 3-methylene-1-(trifluoromethyl)cyclobutane-1-carbonitrile and 3-methylene-1-(trifluoromethyl)cyclobutane-1-carboxylic acid. The synthesized compounds contain trifluoromethyl group near the functional one (carboxylic or amino group) and are promising for further application in drug discovery.

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