Індольний алкалоїд еліптицин як ефективна багатоцільова сполука

• Date: 2022
• Author Affiliations: Kostiantyn V. Shvydenko — Institute of Organic Chemistry of the National Academy of Sciences of Ukraine, 5 Murmanska St., Kyiv, 02660, Ukraine; Iryna A. Grafova — Department of Chemistry, University of Helsinki, Helsinki 01560, Finland; Tetiana I. Shvydenko — Institute of Organic Chemistry of the National Academy of Sciences of Ukraine, 5 Murmanska St., Kyiv, 02660, Ukraine; Aleksandr N. Kostyuk — Institute of Organic Chemistry of the National Academy of Sciences of Ukraine, 5 Murmanska St., Kyiv, 02660, Ukraine; Neila S. Picanço — Laboratory of Malaria and Dengue, National Institute of Amazonian Research (INPA), Manaus 69067-375, Amazonas, Brazil; Luiz F.R. Silva — Biotechnology Center of Amazonia, INPA, Manaus 69067-375, Amazonas, Brazil; Anya Kropfitsch — International Centre for Genetic Engineering and Biotechnology, Cape Town Component, Cape Town 7935, South Africa; Claudia D.C. Wyrepkowski — Laboratory of Leishmaniasis and Chagas Disease, INPA, Manaus 69067-375, Amazonas, Brazil; Luiz F. Zerbini — International Centre for Genetic Engineering and Biotechnology, Cape Town Component, Cape Town 7935, South Africa; Wanderli P. Tadei — Laboratory of Malaria and Dengue, National Institute of Amazonian Research (INPA), Manaus 69067-375, Amazonas, Brazil; Antonia M.R.F. Pereira — Laboratory of Leishmaniasis and Chagas Disease, INPA, Manaus 69067-375, Amazonas, Brazil; Markku Leskelä — Department of Chemistry, University of Helsinki, Helsinki 01560, Finland; Andriy V. Grafov — Department of Chemistry, University of Helsinki, Helsinki 01560, Finland
• Keywords: keywords
• Main Authors: Shvydenko, Kostiantyn V., Grafova, Iryna A., Shvydenko, Tetiana I., Kostyuk, Aleksandr N., Picanço, Neila S., Silva, Luiz F.R., Kropfitsch, Anya, Wyrepkowski, Claudia D.C., Zerbini, Luiz F., Tadei, Wanderli P., Pereira, Antonia M.R.F., Leskelä, Markku, Grafov, Andriy V.
• Format: Article
• Language: English
• Published: V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine 2022
• Subjects: фтор; піролізидин; індолізидин; хінолізидинові алкалоїди; стратегія синтезу
• Online Access: https://bioorganica.com.ua/index.php/journal/article/view/18
• Journal Title: Ukrainica Bioorganica Acta

First isolated from the tropical plant Oschrosia elliptica, indole alkaloid ellipticine provoked huge interest since it demonstrated antitumor activity was demonstrated along with limited toxic side effects and a complete lack of hematological toxicity. In this work, a five-step Cranwell and Saxton...