Похідні цитизину як нові антибактеріальні агенти проти Escherichia coli: in silico та in vitro дослідження

• Date: 2021
• Main Authors: Hodyna, Diana M., Kovalishyn, Vasyl V., Blagodatnyi, Volodymyr M., Bondarenko, Svitlana P., Mrug, Galyna P., Frasinyuk, Mykhaylo S., Metelytsia, Larysa O.
• Format: Article
• Language: English
• Published: V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine 2021
• Subjects: похідні цитизину; QSAR; Escherichia coli; антибактеріальна активність
• Online Access: https://bioorganica.com.ua/index.php/journal/article/view/23
• Journal Title: Ukrainica Bioorganica Acta

QSAR analysis of a 5143 compounds set of previously synthesized compounds tested against multi-drug resistant (MDR) clinical isolate Escherichia coli strains was done by using Online Chemical Modeling Environment (OCHEM).The predictive ability of the regression models was tested through cross-valida...