4-(1-Оксо-1Н-ізохромен-3-іл)бензолсульфонаміди та їхня дія на ріст ракових клітин
Sulfonamide derivatives of 3-phenyl-1H-isochromen-1-one were synthesized by reaction of 4-(1-oxo-1H-isochromen-3-yl)benzenesulfonyl chloride with amines. The specific parameters of chlorosulfonation of 3-phenyl-1H-isochromen-1-one have been identified; the procedure for synthesis of 4-(1-oxo-1H-isoc...
Saved in:
| Date: | 2021 |
|---|---|
| Main Authors: | , , |
| Format: | Article |
| Language: | English |
| Published: |
V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine
2021
|
| Subjects: | |
| Online Access: | https://bioorganica.com.ua/index.php/journal/article/view/24 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Journal Title: | Ukrainica Bioorganica Acta |
Institution
Ukrainica Bioorganica Acta| Summary: | Sulfonamide derivatives of 3-phenyl-1H-isochromen-1-one were synthesized by reaction of 4-(1-oxo-1H-isochromen-3-yl)benzenesulfonyl chloride with amines. The specific parameters of chlorosulfonation of 3-phenyl-1H-isochromen-1-one have been identified; the procedure for synthesis of 4-(1-oxo-1H-isochromen-3-yl)benzenesulfonyl chloride and its by-product (disulfochloride) was optimized. The evaluation of anticancer activity of obtained sulfonamides showed no appreciable cytotoxicity |
|---|