Рецензія на наукову монографію В.П. Хилі, В.С. Москвіної, О.В. Шабликіної, В.В. Іщенко «Хімія флавоноїдів: кумарини та ізокумарини»
Review for a scientific monograph «Chemistry of benzopyrones: coumarins, isocoumarins» by Khilya V.P., Moskvina V.S., Shablykina O.V., Ishchenko V.V.
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| Datum: | 2021 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | Englisch |
| Veröffentlicht: |
V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine
2021
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| Online Zugang: | https://bioorganica.com.ua/index.php/journal/article/view/28 |
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| Назва журналу: | Ukrainica Bioorganica Acta |
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Ukrainica Bioorganica Acta| _version_ | 1871193560283348992 |
|---|---|
| author | Frasinyuk, Mykhaylo S. |
| author_facet | Frasinyuk, Mykhaylo S. |
| author_institution_txt_mv | [
{
"author": "Mykhaylo S. Frasinyuk",
"institution": "V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, 1 Murmanska St., Kyiv, 02094, Ukraine"
}
] |
| author_sort | Frasinyuk, Mykhaylo S. |
| baseUrl_str | https://bioorganica.com.ua/index.php/journal/oai |
| collection | OJS |
| datestamp_date | 2026-07-19T14:56:53Z |
| description | Review for a scientific monograph «Chemistry of benzopyrones: coumarins, isocoumarins» by Khilya V.P., Moskvina V.S., Shablykina O.V., Ishchenko V.V. |
| first_indexed | 2025-07-17T12:19:33Z |
| format | Article |
| fulltext |
ISSN 1814-9758. Ukr. Bioorg. Acta, 2021, Vol. 16, N 2
42
PEER REVIEW
“Chemistry of benzopyrones: coumarins,
isocoumarins”
by Volodymyr P. Khilya, Viktoria S. Moskvina, Olga V. Shablykina and Valentina V. Ishchenko
The study of natural compounds and their synthetic
analogs is an essential practically-oriented research
spanning multiple dimensions: finding and isolating new
substances from plant raw materials, establishing their
structure, studying their chemical and biological properties,
spectral characteristics, etc. Such research plays a crucial
role in deepening our knowledge of biologically active
compounds and provides the basis for creating and
developing drugs with a broad spectrum of action.
The chemistry of natural and synthetic oxygen-
containing compounds has established itself as a traditional
research area at the Department of Organic Chemistry of
Chemical Faculty of the Taras Shevchenko National
University of Kyiv. The presented monograph is dedicated
to the 130th anniversary of the Department of Organic
Chemistry and covers the current state of the chemistry of
coumarins and isocoumarins.
In the monograph that is titled "Chemistry of
benzopyrones: coumarins, isocoumarins", the authors detail
the classical aspects of the coumarin and isocoumarin
chemistry together with the latest advances in their
synthesis and modification, they also consider the present
state of the research space, and provide a significant number
of references both on original papers and other related
reviews.
The monograph consists of seven sections covering the
methods of synthesis and description of chemical and
physical properties of 3-het(aryl)couma-rins, 4-(het)aryl-
coumarins, 3-aryl(hetaryl)isocoumarins, and amino acid
M. S. Frasinyuk
43
derivatives of coumarins, isocoumarins and 3,4-
dihydroisocoumarins.
The first section of the monograph provides a brief
overview of the major approaches to the synthesis of 3-
hetarylcoumarins. They are based on the methods of
annealing the coumarin system to the heterocyclic fragment
or creating a heterocyclic substituent in the coumarin cycle.
The second section deals with the synthesis of 4-aryl-
coumarins and covers the cyclization (Pechmann, Perkin,
Ponndorf reactions, etc.) and arylation methods of both
inactivated coumarins and coumarins activated at the 4th
position. The third section summarizes the methods of
synthesis of 3-arylisocoumarins and 3-hetarylisocoumarins.
The monograph provides an overview of the data on the
interaction of coumarins with sulfur-containing
nucleophiles (thionation reactions) and nitrogen-containing
nucleophilic reagents (Section 4), and reviews the
transformation of 3- (het)arylisocoumarins under the action
of H-, N-, O-, S-nucleophilic reagents (Section 5). Section 6
discusses synthetic approaches to coumarin derivatives with
amino acid or peptide fragments. Finally, Section 7 is
devoted to advances in the field of amino acid derivatives of
isocoumarins and 3,4-dihydroisocoumarins of natural
origin. It is noteworthy that, in addition to methods for
benzopyranone system construction, the final Sections
describe efficient methods for introducing amino acids and
oligopeptides using both classical approaches and novel
reagents for peptide synthesis.
The monograph will be of interest to students, graduate
students, and researchers who are interested in biologically
active compounds and can feature as additional literature in
the educational process for disciplines related to the
chemistry of heterocyclic compounds.
The monograph was published in the publishing and
printing center "Kyiv University" in 2021 and posted on the
website of the Department of Organic Chemistry of Taras
Shevchenko National University of Kyiv:
https://orgchem.knu.ua/upload/metod_chemistry_of_flavon
oids_coumarines_isocoumarines.pdf
QR-code (website link):
D.Sc., Senior Research Scientist,
Department of Bioactive Nitrogen-containing
Heterocyclic compounds of the
V.P. Kukhar Institute of Bioorganic Chemistry &
Petrochemistry of the NAS of Ukraine
Mykhaylo S. Frasinyuk
|
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| institution | Ukrainica Bioorganica Acta |
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| language | English |
| last_indexed | 2026-07-20T01:00:39Z |
| publishDate | 2021 |
| publisher | V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine |
| record_format | ojs |
| resource_txt_mv | bioorganicacomua/d9/9b3a2a153ec99655662fcc1820038bd9.pdf |
| spelling | oai:ojs2.bioorganica.com.ua:article-282026-07-19T14:56:53Z Review for a scientific monograph «Chemistry of benzopyrones: coumarins, isocoumarins» by Khilya V.P., Moskvina V.S., Shablykina O.V., Ishchenko V.V. Рецензія на наукову монографію В.П. Хилі, В.С. Москвіної, О.В. Шабликіної, В.В. Іщенко «Хімія флавоноїдів: кумарини та ізокумарини» Frasinyuk, Mykhaylo S. Review for a scientific monograph «Chemistry of benzopyrones: coumarins, isocoumarins» by Khilya V.P., Moskvina V.S., Shablykina O.V., Ishchenko V.V. Рецензія на наукову монографію В.П. Хилі, В.С. Москвіної, О.В. Шабликіної, В.В. Іщенко «Хімія флавоноїдів: кумарини та ізокумарини» V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine 2021-12-27 Article Article application/pdf https://bioorganica.com.ua/index.php/journal/article/view/28 Ukrainica Bioorganica Acta; Vol. 16 No. 2 (2021): Ukrainica Bioorganica Acta; 42-43 Ukrainica Bioorganica Acta; Том 16 № 2 (2021): Ukrainica Bioorganica Acta; 42-43 1814-9766 1814-9758 10.15407/bioorganica2021.02 en https://bioorganica.com.ua/index.php/journal/article/view/28/32 Copyright (c) 2021 Mykhaylo S. Frasinyuk https://creativecommons.org/licenses/by/4.0 |
| spellingShingle | Frasinyuk, Mykhaylo S. Рецензія на наукову монографію В.П. Хилі, В.С. Москвіної, О.В. Шабликіної, В.В. Іщенко «Хімія флавоноїдів: кумарини та ізокумарини» |
| title | Рецензія на наукову монографію В.П. Хилі, В.С. Москвіної, О.В. Шабликіної, В.В. Іщенко «Хімія флавоноїдів: кумарини та ізокумарини» |
| title_alt | Review for a scientific monograph «Chemistry of benzopyrones: coumarins, isocoumarins» by Khilya V.P., Moskvina V.S., Shablykina O.V., Ishchenko V.V. |
| title_full | Рецензія на наукову монографію В.П. Хилі, В.С. Москвіної, О.В. Шабликіної, В.В. Іщенко «Хімія флавоноїдів: кумарини та ізокумарини» |
| title_fullStr | Рецензія на наукову монографію В.П. Хилі, В.С. Москвіної, О.В. Шабликіної, В.В. Іщенко «Хімія флавоноїдів: кумарини та ізокумарини» |
| title_full_unstemmed | Рецензія на наукову монографію В.П. Хилі, В.С. Москвіної, О.В. Шабликіної, В.В. Іщенко «Хімія флавоноїдів: кумарини та ізокумарини» |
| title_short | Рецензія на наукову монографію В.П. Хилі, В.С. Москвіної, О.В. Шабликіної, В.В. Іщенко «Хімія флавоноїдів: кумарини та ізокумарини» |
| title_sort | рецензія на наукову монографію в.п. хилі, в.с. москвіної, о.в. шабликіної, в.в. іщенко «хімія флавоноїдів: кумарини та ізокумарини» |
| url | https://bioorganica.com.ua/index.php/journal/article/view/28 |
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