Створення бібліотеки N-(2,4-діарилтіазол-5-іл)бензамідинів та вплив цих сполук на ріст ракових клітин

• Date: 2022
• Author Affiliations: Oleksandr O. Severin — V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, Kyiv, Ukraine; Maryna V. Kachaeva — V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, Kyiv, Ukraine; Stepan G. Pilyo — V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, Kyiv, Ukraine; Olga V. Shablykina — V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, Kyiv, Ukraine; Taras Shevchenko National University of Kyiv, Kyiv, Ukraine; Viktoriia S. Moskvina — V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, Kyiv, Ukraine; Taras Shevchenko National University of Kyiv, Kyiv, Ukraine; Volodymyr S. Brovarets — V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, Kyiv, Ukraine
• Keywords: keywords
• Main Authors: Severin, Oleksandr O., Kachaeva, Maryna V., Pilyo, Stepan G., Shablykina, Olga V., Moskvina, Viktoriia S., Brovarets, Volodymyr S.
• Format: Article
• Language: English
• Published: V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine 2022
• Subjects: N-(2,4-діарилтіазол-5-іл)бензамідини; комбінаторна бібліотека; антиракова активність
• Online Access: https://bioorganica.com.ua/index.php/journal/article/view/31
• Journal Title: Ukrainica Bioorganica Acta

A versatile and efficient protocol for the synthesis of library of N-(2,4-diarylthiazol-5-yl)benzamidines is described. We obtained a library of 25 diversity with different of substituents in four positions in key framework. The synthesized amidine derivatives were evaluated for their i...