5-Заміщені N-(9Н-пурин-6-іл)-1,2-оксазол-3-карбоксаміди як інгібітори ксантиноксидази

• Date: 2020
• Main Authors: Muzychka, Oksana V., Kobzar, Oleksandr L., Shablykin, Oleh V., Brovarets, Volodymyr S., Vovk, Andriy I.
• Format: Article
• Language: English
• Published: V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine 2020
• Subjects: N-(9Н-пурин-6-іл)-1,2-оксазол-3-карбоксаміди; синтез; біоактивність; ксантиноксидаза
• Online Access: https://bioorganica.com.ua/index.php/journal/article/view/4
• Journal Title: Ukrainica Bioorganica Acta

Synthetic 6-substituted purine derivatives are known to exhibit diverse bioactivity. In this paper, a series of N-(9H-purin-6-yl)-1,2-oxazole-3-carboxamide derivatives were synthesized and evaluated in vitro against xanthine oxidase, an enzyme of purine catabolism. The introduction of aryl substitue...