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Нові сульфамідні похідні 4-іміногідантоїну з противірусною та протираковою активністю

Нові сульфамідні похідні 4-іміногідантоїну з противірусною та протираковою активністю

A number of sulfamides were obtained by reaction interaction of (5-(dichloromethylene)-2-oxoimidazolidin-4-ylidene)sulfamoyl chloride with anilines, benzylamines, Boc-protected piperazine, methylalylamine, and amino acids methyl esters with primary and secondary amino group. The antiviral and antica...

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Bibliographic Details
Main Authors: Kornii, Yurii Eu., Shablykin, Oleh V., Shablykina, Olga V., Brovarets, Volodymyr S.
Format: Article
Language:English
Published: V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine 2021
Subjects:
hydantoins
sulfamides
antiviral activity
anticancer activity
гідантоїни
сульфаміди
противірусна активність
протипухлинна активність
Online Access:https://bioorganica.com.ua/index.php/journal/article/view/43
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Summary:A number of sulfamides were obtained by reaction interaction of (5-(dichloromethylene)-2-oxoimidazolidin-4-ylidene)sulfamoyl chloride with anilines, benzylamines, Boc-protected piperazine, methylalylamine, and amino acids methyl esters with primary and secondary amino group. The antiviral and anticancer activity of new derivatives was evaluated. The most effective compounds against Human cytomegalovirus were sulfamides based on anisidine (1b), N-Boc-piperazine (1h), and the derivatives 1n, o with fragments of nipecotic and azetidine-3-carboxylic acids, respectively. Anticancer activity was most significant for sulfamides based on p-methoxybenzylamine (compound 1d), benzylmethylamine (compound 1f), and allylmethylamine (compound 1g).

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