Синтез нових піразолін-тіазолідин-4-онових гібридних молекул та оцінка їх біологічної активності
In the present work, the synthesis of pyrazoline-thiazolidin-4-one hybrids and their pharmacological properties are described. The structure of compounds is characterized using 1H, 13C NMR, and LC-MS spectra. The antioxidant (DPPH assay), antimicrobial (Gram-positive bacterium Lactobacillus plantaru...
Збережено в:
| Видавець: | V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine |
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| Дата: | 2021 |
| Автор: | |
| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine
2021
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| Теми: | |
| Онлайн доступ: | https://bioorganica.com.ua/index.php/journal/article/view/44 |
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Репозиторії
Ukrainica Bioorganica Acta| Резюме: | In the present work, the synthesis of pyrazoline-thiazolidin-4-one hybrids and their pharmacological properties are described. The structure of compounds is characterized using 1H, 13C NMR, and LC-MS spectra. The antioxidant (DPPH assay), antimicrobial (Gram-positive bacterium Lactobacillus plantarum, Gram-negative bacterium Escherichia coli, and yeasts Candida albicans, MIC determination), redox (cyclic voltammetry) as well as herbicidal activity (against grass species Agrostis stolonifera) of compounds have been studied. All derivatives have demonstrated radical scavenging activity with IC50 values in the range of 4.67-7.12 mM that were measured by the DPPH test. The tested compounds showed very low antimicrobial and herbicidal activity and no redox peaks were observed in the cyclic voltammetry studies |
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