In vitro та in silico дослідження 1,3-оксазол-4- ілтрифенілфосфонієвих солей як потенційних інгібіторів трансглікозилази Candida albicans

• Date: 2021
• Author Affiliations: Ivan V. Semenyuta — V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, 1 Murmanska St., Kyiv, 02094, Ukraine; Maria M. Trush — V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, 1 Murmanska St., Kyiv, 02094, Ukraine; Diana M. Hodyna — V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, 1 Murmanska St., Kyiv, 02094, Ukraine; Maryna V. Kachaeva — V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, 1 Murmanska St., Kyiv, 02094, Ukraine; Larysa O. Metelytsia — V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, 1 Murmanska St., Kyiv, 02094, Ukraine; Volodymyr S. Brovarets — V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, 1 Murmanska St., Kyiv, 02094, Ukraine
• Keywords: keywords
• Main Authors: Semenyuta, Ivan V., Trush, Maria M., Hodyna, Diana M., Kachaeva, Maryna V., Metelytsia, Larysa O., Brovarets, Volodymyr S.
• Format: Article
• Language: English
• Published: V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine 2021
• Subjects: трансглікозилаза; трифенілфосфонієві солі; 1,3-оксазол; Candida albicans; Staphylococcus aureus
• Online Access: https://bioorganica.com.ua/index.php/journal/article/view/45
• Journal Title: Ukrainica Bioorganica Acta

The previously established in vitro high antimicrobial activity of triphenylphosphonium salts (TPPs) against bacterial (Staphylococcus aureus ATCC 25923 and multi-drug resistant (MDR)) and fungal (Candida albicans ATCC 10231 and MDR) strains made it possible to propose a molecular mechanism of actio...