Нові фосфорильовані 5-(гідроксіалкіламіно)-1,3-оксазоли як потенційні протипухлинні агенти

• Дата: 2023
• Автори: Bahrieieva, Oksana S., Golovchenko, Oleksandr V., Golovchenko, Oksana I., Zhirnov, Victor V., Brovarets, Volodymyr S.
• Формат: Стаття
• Мова: English
• Опубліковано: V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine 2023
• Онлайн доступ: https://bioorganica.com.ua/index.php/journal/article/view/54
• Назва журналу: Ukrainica Bioorganica Acta

Eight new phosphorylated 5-(hydroxyalkylamino)-1,3-oxazoles were designed and tested for their ability to inhibit cancer cell growth. These compounds were evaluated against complete human tumor cell lines NCI-60. Only three compounds showed antitumor activity in the single dose assay, which were tak...