2,2-Дизаміщені 5- та 8-азахроман-4-они: вплив на ріст ракових клітин у порівнянні з хроманоновими аналогами

• Date: 2023
• Main Authors: Malets, Yehor S., Golovchenko, Oleksandr V.
• Format: Article
• Language: English
• Published: V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine 2023
• Subjects: гетероцикли; хроманони; азахроманони; протиракова активніст
• Online Access: https://bioorganica.com.ua/index.php/journal/article/view/66
• Journal Title: Ukrainica Bioorganica Acta

A series of 2,2-disubstituted 5-azachroman-4-ones (two examples) and isomeric 8-azachroman-4-ones (four derivatives) were evaluated for their in vitro anticancer activity on 60 cancer cell lines. The decreased proliferation of cancer cells was observed for the case of both types of isomeric azachrom...