Дослідження амінометилкумаринів: універсальний синтез, структурна різноманітність, прогнозування ADME параметрів
This research presents a highly efficient method for synthesizing diverse aminomethylcoumarin libraries through the interaction of Mannich bases of coumarins and primary amines. The developed amination process demonstrated versatility and compatibility with various substituents. Reactions were compl...
Збережено в:
| Видавець: | V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine |
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| Дата: | 2023 |
| Автори: | , , , |
| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine
2023
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| Теми: | |
| Онлайн доступ: | https://bioorganica.com.ua/index.php/journal/article/view/74 |
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Репозиторії
Ukrainica Bioorganica Acta| Резюме: | This research presents a highly efficient method for synthesizing diverse aminomethylcoumarin libraries through the interaction of Mannich bases of coumarins and primary amines. The developed amination process demonstrated versatility and compatibility with various substituents. Reactions were completed within short timeframes, yielding high-purity products with substantial yields, as well as facilitating the scale-up of the process. The synthesized derivatives exhibited structural diversity, incorporating carboxylic and amino groups, as well as amide, hydrazide, and hydroxamic acid moieties. In silico ADME predictions highlighted the potential of these aminomethylcoumarins as promising candidates for further optimization in the development of oral chemotherapeutic agents |
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