4-(Фуран-2-іл)бензойні кислоти на основі роданіну як інгібітори ксантиноксидази

• Date: 2023
• Author Affiliations: Alona V. Beiko — V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, Kyiv, Ukraine; Oleksandr L. Kobzar — V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, Kyiv, Ukraine; Maryna V. Kachaeva — V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, Kyiv, Ukraine; Stepan G. Pilyo — V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, Kyiv, Ukraine; Olexandr P. Kozachenko — V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, Kyiv, Ukraine; Andriy I. Vovk — V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, Kyiv, Ukraine
• Keywords: keywords
• Main Authors: Beiko, Alona V., Kobzar, Oleksandr L., Kachaeva, Maryna V., Pilyo, Stepan G., Kozachenko, Olexandr P., Vovk, Andriy I.
• Format: Article
• Language: English
• Published: V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine 2023
• Subjects: роданін; 4-(фуран-2-іл)бензойна кислота; ксантиноксидаза; інгібування; молекулярний докінг; молекулярна динаміка
• Online Access: https://bioorganica.com.ua/index.php/journal/article/view/75
• Journal Title: Ukrainica Bioorganica Acta

A series of rhodanine derivatives bearing 4-(furan-2-yl)benzoic acid moiety were synthesized and studied as inhibitors of xanthine oxidase. This enzyme is a known target for allopurinol and febuxostat used in the treatment of hyperuricemia, gout, and other diseases. The synthesized compounds with di...