Нові ліки, які з’явилися на ринку в 2023 році: молекули, що містять флуор та модифіковані амінокислотні фрагменти

• Видавець: V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine
• Дата: 2024
• Автори: Han, Jianlin, Wzorek, Alicja, Dhawan, Gagan, Zhang, Wei, Sorochinsky, Alexander E., Ono, Taizo, Soloshonok, Vadim A.
• Формат: Стаття
• Мова: English
• Опубліковано: V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine 2024
• Теми: pharmaceuticals; amino acids; fluorine-containing compounds; drug design and development; фармацевтичні препарати; амінокислоти; флуоровмісні сполуки; дизайн і розробка ліків
• Онлайн доступ: https://bioorganica.com.ua/index.php/journal/article/view/79

Dedication: As we celebrate Professor Iwao Ojima's 80th birthday on June 5th, 2025, we express gratitude for his dedication to chemistry, mentoring, and friendship. His teaching style, blending expertise and enthusiasm, has inspired countless students and colleagues. His kindness, guidance, and encouragement have nurtured lasting bonds. We honor his remarkable achievements and the lives he's touched This article profiles eight new FDA-approved drugs containing fluorine along with the fragments of amino acids or their derivatives. These pharmaceuticals include Eflornithine, Lotilaner, Leniolisib, Fezolinetant, Nirmatrelvir, Repotrectinib, Nirogacestat, and Pirtobrutinib, representing such therapeutic areas as cancer, neuromuscular disorder, immunodeficiency, virology, and infectious diseases. Importance of fluorination, amino acid residues as well as chirality in the design of new pharmaceuticals is highlighted