Нові ліки, які з’явилися на ринку в 2023 році: молекули, що містять флуор та модифіковані амінокислотні фрагменти

• Дата: 2024
• Автори та афіліації: Jianlin Han — Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing, China; Alicja Wzorek — Institute of Chemistry, Jan Kochanowski University in Kielce, Kielce, Poland; Gagan Dhawan — DAcharya Narendra Dev College, University of Delhi, New Delhi, India; Wei Zhang — University of Massachusetts Boston, Boston, MA, USA; Alexander E. Sorochinsky — V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, Kyiv, Ukraine; Taizo Ono — National Institute of Advanced Industrial Science and Technology (AIST), Anagahora, Shimoshidami, Moriyama-ku, Nagoya, Japan; Vadim A. Soloshonok — University of the Basque Country, San Sebastián, Spain; IKERBASQUE, Basque Foundation for Science, Bilbao, Spain
• Ключові слова: keywords
• Автори: Han, Jianlin, Wzorek, Alicja, Dhawan, Gagan, Zhang, Wei, Sorochinsky, Alexander E., Ono, Taizo, Soloshonok, Vadim A.
• Формат: Стаття
• Мова: Англійська
• Опубліковано: V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine 2024
• Теми: фармацевтичні препарати; амінокислоти; флуоровмісні сполуки; дизайн і розробка ліків
• Онлайн доступ: https://bioorganica.com.ua/index.php/journal/article/view/79
• Назва журналу: Ukrainica Bioorganica Acta

Dedication: As we celebrate Professor Iwao Ojima's 80th birthday on June 5th, 2025, we express gratitude for his dedication to chemistry, mentoring, and friendship. His teaching style, blending expertise and enthusiasm, has inspired countless students and colleagues. His kindness, guidance, and encouragement have nurtured lasting bonds. We honor his remarkable achievements and the lives he's touched This article profiles eight new FDA-approved drugs containing fluorine along with the fragments of amino acids or their derivatives. These pharmaceuticals include Eflornithine, Lotilaner, Leniolisib, Fezolinetant, Nirmatrelvir, Repotrectinib, Nirogacestat, and Pirtobrutinib, representing such therapeutic areas as cancer, neuromuscular disorder, immunodeficiency, virology, and infectious diseases. Importance of fluorination, amino acid residues as well as chirality in the design of new pharmaceuticals is highlighted